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首页> 外文期刊>Journal of Biomechanics >Estimation of optimal insertion angle in a mammalian outer hair cell stereocilium
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Estimation of optimal insertion angle in a mammalian outer hair cell stereocilium

机译：估计哺乳动物外毛细胞立体感的最佳插入角度

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摘要

Optimal insertion angle of mammalian stereocilia is estimated from the finite element analysis of the tip motion of outer hair cells (OHCs) stereocilia. The OHC stereocilia motion in the acousticolateral system appears to result in the mechanoelectrical transduction channels. Deflection of the hair bundle towards the tallest row of stereocilia causes increased probability of opening of ion channels. In this work, we focus on one of the physical features of the OHC stereocilium, the initial insertion angle of the tallest row into the tectorial membrane (TM), and its effects on the stereocilia's deflection motion. A three-dimensional model was built for the tallest stereocilium and the TM at the region where the best frequency was 500. Hz. The mechanical interactions between the embedded stereocilia and the TM have been implemented into the finite element simulation. We found that, the optimum insertion angle of the tallest stereocilium into the TM was 69.8°, where the stereocilium is maximally deflected. This quantity is consistent with the histological observation obtained from the literature.
机译：哺乳动物立体纤毛的最佳插入角度是通过对外部毛细胞（OHC）立体纤毛的尖端运动的有限元分析来估算的。 OHC立体纤毛运动在听外侧系统中似乎产生了机械电传导通道。头发束朝着最高的立体纤毛行偏转会增加打开离子通道的可能性。在这项工作中，我们重点关注OHC立体纤毛的物理特征，最高的一排插入到覆膜（TM）的初始插入角度及其对立体纤毛偏转运动的影响。在最高频率为500 Hz的区域建立了最高立体音响和TM的三维模型。嵌入的立体纤毛和TM之间的机械相互作用已实现到有限元模拟中。我们发现，最高的立体纤毛插入TM的最佳插入角度为69.8°，此时立体纤毛发生最大偏转。该量与从文献中获得的组织学观察结果一致。

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