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首页> 外文期刊>Journal of Biomechanics >In situ biomechanical properties of normal and diabetic nerves: An efficient quasi-linear viscoelastic approach.
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In situ biomechanical properties of normal and diabetic nerves: An efficient quasi-linear viscoelastic approach.

机译：正常和糖尿病神经的原位生物力学特性：一种有效的准线​​性粘弹性方法。

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摘要

Biomechanical properties of nerves were investigated using the quasi-linear viscoelastic model. An improved parameter estimation technique based on fast convolution was developed and tested in sciatic nerves of normal and diabetic rats. In situ dynamic compression response of sciatic nerves was obtained by a modified custom-designed compression system. Six normal and five diabetic neuropathic Wistar rats were used. The model derived from the high strain rate (0.1 s(-1)) data could predict the responses of lower strain rates (0.05 and 0.01 s(-1)) satisfactorily. The computation time was cut down 49.0% by using the newly developed technique without increasing the root-mean-square error. The percentage of stress relaxation of the diabetic and normal rats, calculated directly from the experimental data, was not significantly different (51.03+/-1.96% vs. 55.97+/-5.89%, respectively; p=0.247). After model fitting, compared with the QLV parameters of normal nerves, the smaller parameter C for diabetic nerves (0.27+/-0.06 vs. 0.20+/-0.02, p < 0.05) indicated that diabetic nerves had a smaller amplitude of viscous response (stress relaxation). The larger parameter tau(2) of diabetic nerves (199+/-153 s vs. 519+/-337 s, p<0.05) implied that diabetic nerves needed a longer relaxation period to reach equilibrium.
机译：使用准线性粘弹性模型研究了神经的生物力学特性。开发了一种改进的基于快速卷积的参数估计技术，并在正常和糖尿病大鼠的坐骨神经中进行了测试。通过修改的定制设计的压缩系统获得了坐骨神经的原位动态压缩响应。使用六只正常和五只糖尿病性神经性Wistar大鼠。从高应变率（0.1 s（-1））数据得出的模型可以令人满意地预测较低应变率（0.05和0.01 s（-1））的响应。使用新开发的技术可将计算时间减少49.0％，而不会增加均方根误差。直接从实验数据计算的糖尿病和正常大鼠的应力松弛百分比没有显着差异（分别为51.03 +/- 1.96％与55.97 +/- 5.89％; p = 0.247）。模型拟合后，与正常神经的QLV参数相比，糖尿病神经的较小参数C（0.27 +/- 0.06与0.20 +/- 0.02，p <0.05）表明，糖尿病神经的粘性反应幅度较小（应力松弛）。糖尿病神经的较大参数tau（2）（199 +/- 153 s vs. 519 +/- 337 s，p <0.05）暗示糖尿病神经需要更长的松弛时间才能达到平衡。

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