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首页> 外文期刊>Journal of Biomechanics >Multiscale modeling of bone tissue with surface and permeability control.
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Multiscale modeling of bone tissue with surface and permeability control.

机译：具有表面和渗透性控制的骨组织多尺度建模。

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摘要

Natural biological materials usually present a hierarchical arrangement with various structural levels. The biomechanical behavior of the complex hierarchical structure of bone is investigated with models that address the various levels corresponding to different scales. Models that simulate the bone remodeling process concurrently at different scales are in development. We present a multiscale model for bone tissue adaptation that considers the two top levels, whole bone and trabecular architecture. The bone density distribution is calculated at the macroscale (whole bone) level, and the trabecular structure at the microscale level takes into account its mechanical properties as well as surface density and permeability. The bone remodeling process is thus formulated as a material distribution problem at both scales. At the local level, the biologically driven information of surface density and permeability characterizes the trabecular structure. The model is tested by a three-dimensional simulation of bone tissue adaptation for the human femur. The density distribution of the model shows good agreement with the actual bone density distribution. Permeability at the microstructural level assures interconnectivity of pores, which mimics the interconnectivity of trabecular bone essential for vascularization and transport of nutrients. The importance of this multiscale model relays on the flexibility to control the morphometric parameters that characterize the trabecular structure. Therefore, the presented model can be a valuable tool to define bone quality, to assist with diagnosis of osteoporosis, and to support the development of bone substitutes.
机译：天然生物材料通常呈现出具有各种结构水平的层次结构。使用解决对应于不同尺度的各个级别的模型来研究骨骼的复杂层次结构的生物力学行为。正在开发同时模拟不同规模的骨骼重塑过程的模型。我们提出了一种用于骨骼组织适应的多尺度模型，其中考虑了两个最高级别，即整个骨骼和小梁结构。骨密度分布是在宏观（整个骨骼）水平上计算的，而在微观尺度上的骨小梁结构则考虑到其机械性能以及表面密度和渗透性。因此，将骨骼重塑过程表述为这两个方面的材料分布问题。在局部水平上，生物驱动的表面密度和渗透性信息表征了小梁结构。通过对人股骨的骨组织适应性的三维模拟来测试该模型。模型的密度分布与实际的骨密度分布显示出良好的一致性。在微结构水平上的渗透性确保了孔的互连性，这模仿了小梁骨的互连性，这对于血管化和营养物质的运输至关重要。这种多尺度模型的重要性在于控制表示小梁结构特征的形态学参数的灵活性。因此，提出的模型可能是定义骨质量，协助诊断骨质疏松症和支持骨替代物开发的有价值的工具。

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