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首页> 外文期刊>Journal of Biomechanics >Fluid-structure interaction based study on the physiological factors affecting the behaviors of stented and non-stented thoracic aortic aneurysms.
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Fluid-structure interaction based study on the physiological factors affecting the behaviors of stented and non-stented thoracic aortic aneurysms.

机译：基于流体-结构相互作用的生理因素影响支架和非支架胸主动脉瘤行为的研究。

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摘要

Endovascular aneurysm repair (EVAR) is considered as a promising alternative technique for the treatment of aortic aneurysm. However, complications often occur after EVAR. In this paper, the influence of the physiological factors on the biomechanical behaviors of stented and non-stented thoracic aortic aneurysm (TAA) were presented. Representative TAA models with different intraluminal thrombus (ILT) volume before and after stent-graft (SG) implantation were built. Fluid-structure interaction effect was taken into account. The relative sliding between the SG wall and the aortic wall was allowed. Results showed that the cardiac cycle and ILT volume should be given much more consideration than previously thought in future investigations on TAA compliance. The time-averaged longitudinal displacement of SG necks were not uniformly distributed along circumferential direction of the aortic wall. Drag force increased with the increase of the cardiac cycle and decreased with the decrease of ILT volume. Computational results of TAA wall stress, sac and lumen pressure indicated that patient with faster heart rate might be at great risk of aneurysm rupture. The stress absorption effect of the SG was influenced by both ILT and cardiac cycle, which was also found to have strong impact on flow pattern. We believe that this study will bring new insights into further researches on the relevant issues and provide mechanics-based implications for clinical management of EVAR for TAA patient.
机译：血管内动脉瘤修复（EVAR）被认为是治疗主动脉瘤的一种有前途的替代技术。但是，EVAR后常发生并发症。本文介绍了生理因素对有支架和无支架胸主动脉瘤（TAA）的生物力学行为的影响。建立了支架植入物（SG）植入前后的不同腔内血栓（ILT）体积的代表性TAA模型。考虑了流固耦合效应。 SG壁和主动脉壁之间的相对滑动是允许的。结果表明，心动周期和ILT量应比在将来对TAA依从性的调查中所考虑的要多得多。 SG颈的时间平均纵向位移沿主动脉壁的圆周方向分布不均匀。阻力随着心动周期的增加而增加，而随着ILT体积的减少而减小。 TAA壁应力，囊和管腔压力的计算结果表明，心律加快的患者可能有动脉瘤破裂的巨大风险。 SG的应力吸收效果受ILT和心动周期的影响，也发现其对血流形态有很大影响。我们相信，这项研究将为有关问题的进一步研究带来新的见识，并为TAA患者的EVAR临床管理提供基于力学的意义。

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