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首页> 外文期刊>Journal of biomedical materials research, Part A >Volumetric bone regenerative efficacy of biphasic calcium phosphate-collagen composite block loaded with rhBMP-2 in vertical bone augmentation model of a rabbit calvarium
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Volumetric bone regenerative efficacy of biphasic calcium phosphate-collagen composite block loaded with rhBMP-2 in vertical bone augmentation model of a rabbit calvarium

机译：rhBMP-2负载的磷酸钙-胶原双相复合材料块在兔颅骨垂直骨增强模型中的体积骨再生功效

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摘要

Block-type biphasic calcium phosphate (BCP) carriers are more effective at delivering recombinant human bone morphogenetic protein-2 (rhBMP-2) in various clinical situations than are particle-type carriers, due to their potential for highly successful three-dimensional bone regeneration. The aim of this study was to confirm the boneregenerative capabilities of three-dimensional BCP blocks with a low hydroxyapatite/β-tricalcium phosphate ratio (20/80) combined with collagen (10% wt) as an rhBMP-2 delivery system in a craniofacial vertical bone augmentation model. BCP blocks and BCP-collagen blocks (with average macropore sizes of 296 and 390 μm, respectively) with or without rhBMP-2 were fixed with osteosynthesis screws to the calvarial surface of rabbits. After 8 weeks, histologic and histomorphometric analyses were performed to evaluate the resulting new bone area, augmented area, bone density, and degree of integration. The area of new bone was significantly greater in specimens containing rhBMP-2 than in the control group (p< 0.05). Moreover, the area fractions of newly formed bone within the augmented area and a degree of integration between the regenerative bone and the calvarium were both significantly greater in the BCP-collagen/rhBMP-2 group than in the BCP/rhBMP-2 group (p< 0.05), whereas the two carrier systems exhibited similar rhBMP-2 release profiles, with sustained and linear release. The BCP and BCP/rhBMP-2 blocks exhibited excellent structural integrity, with large fragments of residual ceramic. In conclusion, the BCP-collagen composite block exhibited enhanced osteoinductive potential and could be a good candidate as a carrier of rhBMP-2 due to its characteristics of favorable volumetric stability, ease of handling, and excellent remodeling properties.
机译：嵌段型双相磷酸钙（BCP）载体在各种临床情况下比颗粒型载体更有效地递送重组人骨形态发生蛋白2（rhBMP-2），因为它们具有成功实现三维骨再生的潜力。这项研究的目的是确认具有低羟基磷灰石/β-磷酸三钙比例（20/80）和胶原蛋白（10％wt）的三维BCP块在颅面中作为rhBMP-2递送系统的骨再生能力垂直骨增强模型。将带有或不带有rhBMP-2的BCP块和BCP胶原块（分别具有296和390μm的平均大孔尺寸）用骨合成螺钉固定在兔的颅骨表面。 8周后，进行组织学和组织形态分析，以评估产生的新骨面积，增大的面积，骨密度和整合度。含有rhBMP-2的标本中新骨的面积显着大于对照组（p <0.05）。此外，BCP-胶原蛋白/ rhBMP-2组的新形成的骨在增大区域内的面积分数以及再生骨与颅骨之间的整合度均显着大于BCP / rhBMP-2组（p <0.05），而两种载体系统表现出相似的rhBMP-2释放曲线，具有持续和线性释放。 BCP和BCP / rhBMP-2嵌段具有出色的结构完整性，并带有大量残留的陶瓷碎片。总之，BCP-胶原蛋白复合物块具有增强的骨诱导潜力，并且由于其良好的体积稳定性，易处理性和出色的重塑特性，因此可以作为rhBMP-2的载体。

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