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首页> 外文期刊>Journal of Biomechanics >Effect of non-Newtonian and pulsatile blood flow on mass transport in the human aorta.
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Effect of non-Newtonian and pulsatile blood flow on mass transport in the human aorta.

机译：非牛顿和脉动血流对人主动脉传质的影响。

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摘要

To investigate the effects of both non-Newtonian behavior and the pulsation of blood flow on the distributions of luminal surface LDL concentration and oxygen flux along the wall of the human aorta, we numerically compared a non-Newtonian model with the Newtonian one under both steady flow and in vivo pulsatile flow conditions using a human aorta model constructed from MRI images. The results showed that under steady flow conditions, although the shear thinning non-Newtonian nature of blood could elevate wall shear stress (WSS) in most regions of the aorta, especially areas with low WSS, it had little effect on luminal surface LDL concentration (c(w)) in most regions of the aorta. Nevertheless, it could significantly enhance c(w) in areas with high luminal surface LDL concentration through the shear dependent diffusivity of LDLs. For oxygen transport, the shear thinning non-Newtonian nature of blood could slightly reduce oxygen flux in most regions of the aorta, but this effect became much more apparent in areas with already low oxygen flux. The pulsation of blood flow could significantly reduce c(w) and enhance oxygen flux in these disturbed places. In most other regions of the aorta, the oxygen flux was also significantly higher than that for the steady flow simulation. In conclusion, the shear shining non-Newtonian nature of blood has little effect on LDL and oxygen transport in most regions of the aorta, but in the atherogenic-prone areas where luminal surface LDL concentration is high and oxygen flux is low, its effect is apparent. Similar is for the effect of pulsatile flow on the transport of LDLs. But, the pulsation of blood flow can apparently affect oxygen flux in the aorta, especially in areas with low oxygen flux.
机译：为了研究非牛顿行为和血流脉动对沿人主动脉壁的腔表面LDL浓度和氧气通量分布的影响，我们对非牛顿模型和牛顿模型在两种稳态下的数值进行了比较。使用从MRI图像构建的人主动脉模型，研究血流和体内脉动血流情况。结果表明，在稳定流动条件下，尽管血液的剪切稀化非牛顿性质可以在主动脉的大部分区域（尤其是WSS较低的区域）升高壁切应力（WSS），但对管腔表面LDL浓度的影响很小（ c（w））在主动脉的大多数区域。然而，它可以通过剪切依赖的LDL扩散率显着提高具有高腔表面LDL浓度的区域中的c（w）。对于氧气输送，血液的剪切稀化非牛顿特性可以稍微降低主动脉大部分区域的氧气通量，但是这种效果在氧气通量已经很低的区域变得更加明显。在这些受干扰的地方，血流的脉动可以显着降低c（w）并增加氧气通量。在主动脉的大多数其他区域，氧通量也显着高于稳定流模拟的通量。总之，在主动脉的大多数区域，血液的剪切光亮非牛顿性对LDL和氧气的输送几乎没有影响，但是在腔表面LDL浓度高而氧气通量低的易致动脉粥样硬化的区域，其影响是明显的。脉动流对低密度脂蛋白运输的影响类似。但是，血流的脉动显然会影响主动脉中的氧气通量，特别是在氧气通量较低的区域。

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