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首页> 外文期刊>Journal of biomedical materials research, Part A >A simple combined floating and anchored collagen gel for enhancing mechanical strength of culture system.
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A simple combined floating and anchored collagen gel for enhancing mechanical strength of culture system.

机译：一种简单的组合式浮动和锚定胶原蛋白凝胶，可增强培养系统的机械强度。

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摘要

In this study, a simple combined method consisting of floating and anchored collagen gel in a ligament or tendon equivalent culture system was used to produce the oriented fibrils in fibroblast-populated collagen matrices (FPCMs) during the remodeling and contraction of the collagen gel. Orientation of the collagen fibrils along single axis occurred over the whole area of the floating section and most of the fibroblasts were elongated and aligned along the oriented collagen fibrils, whereas no significant orientation of fibrils was observed in normally contracted FPCMs by the floating method. Higher elasticity and enhanced mechanical strength were obtained using our simple method compared with normally contracted floating FPCMs. The Young's modulus and the breaking point of the FPCMs were dependent on the initial cell densities. This simple method will be applied as a convenient bioreactor to study cellular processes of the fibroblasts in the tissues with highly oriented fibrils such as ligaments or tendons.
机译：在这项研究中，由简单的组合方法组成的韧带或肌腱等效培养系统中的浮动和锚定胶原蛋白凝胶被用于在胶原蛋白凝胶的重塑和收缩过程中在成纤维细胞填充的胶原蛋白基质（FPCM）中产生定向的原纤维。胶原纤维的单轴取向发生在整个漂浮区域，并且大多数成纤维细胞被拉长并沿着定向的胶原纤维排列，而在正常收缩的FPCM中，通过漂浮方法未观察到明显的纤维取向。与正常收缩的浮动FPCM相比，使用我们的简单方法可获得更高的弹性和更高的机械强度。 FPCM的杨氏模量和断裂点取决于初始细胞密度。这种简单的方法将用作便利的生物反应器，以研究具有高度定向的原纤维（如韧带或肌腱）的组织中成纤维细胞的细胞过程。

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