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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Characterization of bionanocomposite scaffolds comprised of amine-functionalized gold nanoparticles and silicon carbide nanowires crosslinked to an acellular porcine tendon.
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Characterization of bionanocomposite scaffolds comprised of amine-functionalized gold nanoparticles and silicon carbide nanowires crosslinked to an acellular porcine tendon.

机译：包含胺官能化金纳米粒子和交联至无细胞猪腱的碳化硅纳米线的仿生纳米复合支架的表征。

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摘要

As one of the most common proteins found in the human body, collagen is regarded as biocompatible and has many properties making it ideal for soft-tissue repair applications. However, collagen matrices fabricated from purified forms of collagen are notoriously weak and easily degraded by the body. The extracellular matrix of many tissues including human dermis, porcine dermis, and porcine small intestine submucosa are often utilized instead, and several of these scaffolds are crosslinked. Crosslinking has been shown to improve the mechanical properties of collagenous tissues and increase their resistance to degradation. In this study we investigated two novel "bionanocomposite" materials in which either gold nanoparticles or silicon carbide nanowires were crosslinked to a porcine tendon. Scanning electron micrographs confirmed that the nanomaterials were successfully crosslinked to the tissues. A collagenase assay, tensile testing, flow cytometry, and bioreactor studies were also performed to further characterize the properties of these novel materials. The results of these studies indicated that crosslinking porcine diaphragm tissues with nanomaterials resulted in scaffolds with improved resistance to enzymatic degradation and appropriate biocompatibility characteristics, thus warranting further study of these materials for soft tissue repair and tissue engineering applications.
机译：胶原蛋白是人体中最常见的蛋白质之一，被认为具有生物相容性，并具有许多特性，使其非常适合软组织修复应用。然而，众所周知，由纯化形式的胶原蛋白制成的胶原蛋白基质较弱，容易被人体降解。经常使用包括人真皮，猪真皮和猪小肠粘膜下层在内的许多组织的细胞外基质，并且这些支架中的一些是交联的。已经显示出交联可改善胶原组织的机械性能并增加其抗降解性。在这项研究中，我们研究了两种新型的“生物纳米复合材料”，其中金纳米颗粒或碳化硅纳米线交联到猪腱上。扫描电子显微照片证实纳米材料成功地交联到组织。还进行了胶原酶测定，拉伸试验，流式细胞术和生物反应器研究，以进一步表征这些新型材料的特性。这些研究的结果表明，将猪material肌组织与纳米材料交联可产生具有更高的酶降解抗性和适当的生物相容性特征的支架，因此有必要进一步研究这些材料在软组织修复和组织工程应用中的应用。

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