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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Evaluation of magnesium ions release, biocorrosion, and hemocompatibility of MAO/PLLA-modified magnesium alloy WE42.
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Evaluation of magnesium ions release, biocorrosion, and hemocompatibility of MAO/PLLA-modified magnesium alloy WE42.

机译：评估MAO / PLLA改性镁合金WE42中镁离子的释放，生物腐蚀和血液相容性。

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摘要

Magnesium alloys may potentially be applied as biodegradable metallic materials in cardiovascular stent. However, the high corrosion rate hinders its clinical application. In this study, a new approach was adopted to control the corrosion rate by fabricating a biocompatible micro-arc oxidation/poly-L-lactic acid (MAO/PLLA) composite coating on the magnesium alloy WE42 substrate and the biocompatibility of the modified samples was investigated. The scanning electronic microscope (SEM) images were used to demonstrate the morphology of the samples before and after being submerged in hanks solution for 4 weeks. The degradation was evaluated through the magnesium ions release rate and electrochemical impedance spectroscopy (EIS) test. The biocompatibility of the samples was demonstrated by coagulation time and hemolysis behavior. The result shows that the poly-L-lactic acid (PLLA) effectively improved the corrosion resistance by sealing the microcracks and microholes on the surface of the MAO coating. The modified samples had good compatibility.
机译：镁合金可潜在地用作心血管支架中的可生物降解的金属材料。但是，高腐蚀速率阻碍了其临床应用。在这项研究中，采用了一种新方法来控制腐蚀速率，方法是在镁合金WE42基材上制备生物相容的微弧氧化/聚L-乳酸（MAO / PLLA）复合涂层，改性样品的生物相容性为调查。使用扫描电子显微镜（SEM）图像演示样品在浸入汉克斯溶液中4周之前和之后的形态。通过镁离子释放速率和电化学阻抗谱（EIS）测试评估降解。样品的生物相容性由凝血时间和溶血行为证明。结果表明，聚-L-乳酸（PLLA）通过密封MAO涂层表面的微裂纹和微孔有效地提高了耐腐蚀性。改性样品具有良好的相容性。

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