...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Injectable biphasic calcium phosphate cements as a potential bone substitute
【24h】

Injectable biphasic calcium phosphate cements as a potential bone substitute

机译：注射用双相磷酸钙水泥可作为潜在的骨替代品

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Apatitic calcium phosphate cements (CPCs) have been widely used as bone grafts due to their excellent osteoconductive properties, but the degradation properties are insufficient to stimulate bone healing in large bone defects. A novel approach to overcome the lack of degrad-ability of apatitic CPC involves the development of biphasic CPCs (BCPC) based on tricalcium phosphate (TCP) in both alpha- and beta-polymorphs. The aim of the current study was to prepare and analyze the physicochemical properties of BCPCs based on dual phase alpha/beta-TCP as obtained by heat treatment of pure alpha-TCP. The handling and mechanical characteristics of the samples as well as the degradation behavior under in vitro condition were investigated and compared with a standard monophasic alpha-TCP-based CPC. The results showed that different heat treatments of commercially available alpha-TCP allowed the formation of biphasic calcium phosphate powder with a variety of alpha/beta-TCP ratios. The use of biphasic powder particles as a reactant for CPCs resulted into increased setting and injectability times of the final BCPCs. During hardening of the cements, the amount of apatite formation decreased with increasing beta-TCP content in the biphasic precursor powders. The morphology of the monophasic CPC consisted of plate-like crystals, whereas needle-like crystals were observed for BCPCs. In vitro degradation tests demonstrated that dissolution rate and corresponding calcium release from the set cements increased considerably with increasing beta-TCP content, suggesting that apatitic CPCs can be rendered degradable by using biphasic alpha/beta-TCP as powder precursor phase.
机译：脂肪族磷酸钙水泥（CPC）由于其优异的骨传导性能而被广泛用作骨移植物，但降解性能不足以刺激大骨缺损中的骨愈合。克服缺乏热亲和的CPC降解性的新方法涉及开发基于α-和β-多晶型物的磷酸三钙（TCP）的双相CPC（BCPC）。本研究的目的是基于通过对纯α-TCP进行热处理而获得的双相α/β-TCP来制备和分析BCPC的理化性质。研究了样品的处理和机械特性以及体外条件下的降解行为，并将其与基于标准单相α-TCP的CPC进行了比较。结果表明，可商购获得的α-TCP的不同热处理允许形成具有多种α/β-TCP比率的双相磷酸钙粉末。使用双相粉末颗粒作为CPC的反应物会导致最终BCPC的凝固时间和可注射时间增加。在水泥硬化过程中，随着两相前体粉末中β-TCP含量的增加，磷灰石的形成量减少。单相CPC的形态由板状晶体组成，而对于BCPC则观察到针状晶体。体外降解测试表明，随着β-TCP含量的增加，固结水泥中的溶解速率和相应的钙释放量会随着β-TCP含量的增加而显着增加，这表明通过将双相α/β-TCP用作粉末前体相，可将脂肪族CPC降解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号