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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Biomineralization regulation by nano-sized features in silk fibroin proteins: Synthesis of water-dispersible nano-hydroxyapatite
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Biomineralization regulation by nano-sized features in silk fibroin proteins: Synthesis of water-dispersible nano-hydroxyapatite

机译：丝素蛋白蛋白质中纳米特征的生物矿化调控：水分散性纳米羟基磷灰石的合成

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摘要

In the present study, silk fibroin (SF) was used as a template to prepare nano-hydroxyapatite (nano-HA) via a biomineralization process. We observed that the content of SF affected both the morphology and water dispersibility of nano-HA particles. Scanning electron microscope (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), zetasizer, and Fourier transform infrared spectroscopy (FTIR) were used to examine nano-HA particle features including the surface morphology, aggregation performance, and crystallization. Rod-like nano-HA particles with desired water dispersibility were achieved when the ratio of SF/HA (calculated) was above 7:3. SEM, TEM, and zeta potential results revealed that nano-HA particles were enclosed by the SF which formed a negative charge layer preventing the aggregation of HA nanoparticles in aqueous solution. Moreover, the nano-HA particles were able to re-disperse in water without precipitation for two weeks at room temperature, 60 degrees C, and 90 degrees C. Our work suggested a facile and effective approach of designing water-dispersible nano-HA particles which may have wide potential application in tissue engineering especially bone regeneration. (C) 2014 Wiley Periodicals, Inc.
机译：在本研究中，丝素蛋白（SF）作为模板，通过生物矿化过程制备了纳米羟基磷灰石（nano-HA）。我们观察到，SF的含量会影响纳米HA颗粒的形态和水分散性。扫描电子显微镜（SEM），透射电子显微镜（TEM），X射线衍射（XRD），zetasizer和傅立叶变换红外光谱（FTIR）用于检查纳米HA颗粒的特征，包括表面形态，聚集性能和结晶。当SF / HA的比例（计算值）高于7：3时，获得了具有所需水分散性的棒状纳米HA颗粒。 SEM，TEM和zeta电位结果表明，纳米HA颗粒被SF包裹，形成了一个负电荷层，阻止了HA纳米颗粒在水溶液中的聚集。此外，纳米HA粒子能够在室温，60摄氏度和90摄氏度下在两周内无沉淀的情况下重新分散在水中。我们的工作提出了设计水分散性纳米HA粒子的便捷有效方法在组织工程特别是骨骼再生中可能具有广泛的潜在应用。 （C）2014威利期刊公司

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