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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Biological properties of a thermally crosslinked gelatin film as a novel anti-adhesive material: Relationship between the biological properties and the extent of thermal crosslinking
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Biological properties of a thermally crosslinked gelatin film as a novel anti-adhesive material: Relationship between the biological properties and the extent of thermal crosslinking

机译：热交联的明胶薄膜作为一种新型抗粘材料的生物学性质：生物学性质和热交联程度之间的关系

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In order to prevent postoperative adhesion and the related complications, a thermally crosslinked gelatin (TCG) film was developed and the basic biological properties were examined, paying special attention to the relationship between these properties and the extent of crosslinking of the film. The gelatin films crosslinked thermally for five different time periods (0, 1, 3, 8, and 14 hours) were developed and the following tests were performed. Regarding the material characterization of the films, the water content, the water solubility, and the enzymatic degradation for collagenase were found to be closely related to the duration of thermal crosslinking. In an in vitro study conducted to examine the cell growth of fibroblasts cultured on the films, the degree of cell growth, except no crosslinked film, was less than that observed in the control group, thus suggesting that such effects of the films on fibroblast cell growth may be related with their anti-adhesive effects. In in vivo tests, the films crosslinked for longer time periods (3, 8, and 14 hours) were retained for longer after being implanted into the abdominal cavity in rats and showed a significant anti-adhesive effect in the rat cecum adhesion models, indicating that the biodegradability and anti-adhesive effects of the TCG films depend on the duration of thermal crosslinking. In order to develop useful and effective anti-adhesive gelatin film, it is very important to optimize duration of the thermal crosslinking. t7-.) (C) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 1038: 1511-1518,2015.
机译：为了防止术后粘连及相关并发症，开发了一种热交联明胶（TCG）膜并检查了其基本生物学特性，并特别注意了这些特性与该膜的交联程度之间的关系。显影了五个不同时间段（0、1、3、8和14小时）热交联的明胶薄膜，并进行了以下测试。关于膜的材料表征，发现水含量，水溶性和胶原酶的酶促降解与热交联的持续时间密切相关。在一项检查膜上培养的成纤维细胞生长的体外研究中，除没有交联的膜外，细胞生长程度均低于对照组，因此表明膜对成纤维细胞的这种作用生长可能与其抗粘连作用有关。在体内测试中，将交联的膜较长时间（3、8和14小时）植入大鼠腹腔后保留更长的时间，并且在大鼠盲肠粘连模型中显示出显着的抗粘连作用，表明TCG薄膜的生物降解性和抗粘连效果取决于热交联的持续时间。为了开发有用和有效的抗粘明胶膜，优化热交联的持续时间非常重要。 （7）2014 Wiley Periodicals，Inc.J Biomed Mater Res Part B：Appl Biomater，1038：1511-1518,2015。

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