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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Effects of simulated oxidation on the in vitro wear and mechanical properties of irradiated and melted highly crosslinked UHMWPE
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Effects of simulated oxidation on the in vitro wear and mechanical properties of irradiated and melted highly crosslinked UHMWPE

机译：模拟氧化对辐照和熔融的高交联UHMWPE的体外磨损和力学性能的影响

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摘要

Radiation crosslinked ultrahigh molecular weight polyethylene (UHMWPE) have reduced the wear rate of the bearing surface in total joint arthroplasty and the incidence of peri-prosthetic bone loss due to wear particles. The oxidation potential afforded to the material by the trapped residual free radicals after irradiation was addressed in first generation crosslinked UHMWPEs by using thermal treatments such as annealing or melting after irradiation. Postirradiation melted crosslinked UHMWPE did not contain detectable free radicals at the time of implantation and was expected to be resistant against oxidation for the lifetime of the implants. Recent analyses of long-term retrievals showed it was possible for irradiated and melted UHMWPEs to oxidize in vivo but studies on the effects of oxidation on these materials have been limited. In this study, we determined the effects of in vitro aging on the wear and mechanical properties of irradiated and melted UHMWPE as a function of radiation dose and found that even small amount of oxidation (oxidation index of 0.1) can have detrimental effects on its mechanical properties. There was a gradual increase in the wear rate below an oxidation index of 1 and a drastic increase thereafter. Therefore, it was shown in a simulated environment that oxidation can have detrimental effects to the clinically relevant properties of irradiated and melted UHMWPEs. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 316-322, 2016.
机译：辐射交联的超高分子量聚乙烯（UHMWPE）在全关节置换术中降低了轴承表面的磨损率，并降低了由于磨损颗粒导致的假体周围骨质损失的发生率。在第一代交联的UHMWPE中，通过使用热处理（例如退火或辐射后的熔化）解决了辐照后被捕获的残留自由基赋予材料的氧化电位。辐照后熔化的交联的UHMWPE在植入时不包含可检测的自由基，并且有望在植入物的整个生命周期中抗氧化。最近对长期回收物的分析表明，辐照和熔化的UHMWPE可能在体内氧化，但有关氧化对这些材料的影响的研究却很有限。在这项研究中，我们确定了体外老化对辐照和熔化的UHMWPE的磨损和机械性能的影响，作为辐射剂量的函数，并且发现即使少量的氧化（氧化指数为0.1）也可能对其机械性能产生不利影响属性。低于1的氧化指数时，磨损率逐渐增加，此后急剧增加。因此，在模拟环境中表明，氧化可能会对辐照和熔化的UHMWPE的临床相关特性产生不利影响。 （c）2015 Wiley Periodicals，Inc. J Biomed Mater Res B部分：Appl Biomater，104B：316-322，2016年。

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