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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Identifying Toxic Degradation Products in Cellulose Acetate Dialyzers
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Identifying Toxic Degradation Products in Cellulose Acetate Dialyzers

机译：鉴定醋酸纤维素透析器中的有毒降解产物

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摘要

In September 1996, seven patients at Hospital A suffered conjunctivitis, hearing loss, diminished vision, and headaches 7-24 h after hemodialysis treatment. Eleven-year-old dialysis modules were identified as a common link between these patients. Degradation of the cellulose acetate (CA) material was identified as the cause of this incident. Degradation products were characterized from retrieved CA dialysis membranes. A series of synthesized CA degradation products was tested in vitro to assess toxicity. Based on the toxicity of the material preparations to the cells, animal tests were performed on selected CA degradation extracts and compared to extracts from actual dialysis membranes. Rabbits were IV-injected with extracts from a 13-year-old dialyzer, synthesized model compounds, and compared to controls. Ophthamological evaluation of the rabbits showed eye injury (iritis/ciliary flush) when the animals were treated with the old dialyzer or synthesized model compounds. Isolation and characterization of a toxic fraction from both of these extracts strongly indicated that oxidative stress at some point in the storage or manufacture of CA dialyzers created degradation products that reproduced some of the patient symptoms identified at Hospital A.
机译：1996年9月，A医院的7名患者在进行血液透析治疗7-24小时后出现结膜炎，听力下降，视力下降和头痛。十一岁的透析模块被确定为这些患者之间的共同纽带。醋酸纤维素（CA）材料的降解被确定为此事件的原因。从回收的CA透析膜中表征降解产物。在体外测试了一系列合成的CA降解产物以评估毒性。基于原料制剂对细胞的毒性，对选定的CA降解提取物进行了动物测试，并与实际透析膜的提取物进行了比较。静脉内注射来自13岁透析器的提取物，合成的模型化合物并与对照组进行比较。当用旧的透析仪或合成的模型化合物处理动物时，对兔子的眼科评估显示出眼部受伤（虹膜炎/睫状潮红）。从这两种提取物中的有毒成分的分离和表征都强烈表明，在CA透析仪的存储或制造过程中的某个时刻，氧化应激产生降解产物，该降解产物重现了医院A所确定的某些患者症状。

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