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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Exhaustive Soxhlet Extraction for the Complete Removal of Residual Compounds to Provide a Nonleaching Silicone Elastomer
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Exhaustive Soxhlet Extraction for the Complete Removal of Residual Compounds to Provide a Nonleaching Silicone Elastomer

机译：彻底去除残留化合物以提供非浸出有机硅弹性体的详尽索氏提取

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All commercially available silicone devices contain freely diffusible silicone oils, uncured oligomers, and other impurities (such as catalysts). These residuals have been found in quantities as high as 20percent by weight in commercially available silicone medical devices. The fate and effects of these residuals have been the topic of much debate recently. In this study, a method for complete removal of these residual compounds was investigated. The total amount of extractable residuals was determined through exhaustive Soxhlet extraction of 5 silicone elastomers. LIM 6030 had 6.29percent, LIM 6070 had 5.74percent, Q7-4750 had 3.02percent, Q7-4780 had 3.22percent, and SE1935 had 0.13percent extractables by weight. The amount of silicon containing residuals leaching from both the extracted and nonextracted samples was also evaluated for 3 and 18 days by inductively coiled plasma (ICP) analysis. A significant amount of leachable compounds, reported as ~g Si/mg solid sample, was found in all nonextracted elastomers with the exception of SE1935 compared to blanks. The amount of leachable compounds found in the extracted elastomers was not found to be significantly higher than the amount found in the blanks. The residual compounds in silicone elastomers may be completely removed by exhaustive Soxhlet extraction and the resulting polymer does not leach silicon-containing compounds in vitro.
机译：所有市售的有机硅设备均包含可自由扩散的有机硅油，未固化的低聚物和其他杂质（例如催化剂）。在市售的有机硅医疗器械中，发现这些残留物的含量高达20％（重量）。这些残差的命运和影响最近成为了许多争论的话题。在这项研究中，研究了一种完全去除这些残留化合物的方法。可萃取残渣的总量通过5种有机硅弹性体的索氏抽提确定。 LIM 6030为6.29％，LIM 6070为5.74％，Q7-4750为3.02％，Q7-4780为3.22％，SE1935为0.13％。还通过电感线圈等离子体（ICP）分析评估了从提取的样品和未提取的样品中浸出的含硅残留物的数量，分别为3天和18天。与空白样品相比，在SE1935以外的所有未萃取弹性体中均发现了大量可浸出化合物，以〜g Si / mg固体样品表示。在提取的弹性体中发现的可浸出化合物的量未发现明显高于在空白中发现的可浸出化合物的量。硅橡胶弹性体中的残留化合物可以通过彻底的索氏提取完全去除，所得聚合物不会在体外浸出含硅化合物。

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