...
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Really smart bioconjugates of smart polymers and receptor proteins
【24h】

Really smart bioconjugates of smart polymers and receptor proteins

机译:真正的智能聚合物和受体蛋白的生物结合物

获取原文
获取原文并翻译 | 示例
           

摘要

Over the past l8years we have been deeply involved with the synthesis and applications of stimuli-responsive polymer Systems, especially polymer-biomolecule conjugates. This article summarizes our work with one of these conjugate systems, specifically polymer-protein conjugates. We include conjugates prepared by random polymer conjugation to lysine amino groups, and also those prepared by site-specific conjugation of the polymer to specific amino acid sites that are genetically engineered into the known amino acid sequence of the protein. We describe the preparation and properties of thermally sensitive random conjugates to enzymes and several affinity recognition proteins. We have also prepared site-specific conjugates to streptavidin with temperature-sensitive polymers, pH-sensitive polymers, and light-sensitive polymers. The preparation of these conjugates and their many fascinating applications are reviewed in this article.
机译:在过去的18年中,我们一直致力于刺激响应性聚合物系统(尤其是聚合物-生物分子共轭物)的合成和应用。本文总结了我们使用这些结合物系统之一,特别是聚合物-蛋白质结合物的工作。我们包括通过随机聚合物与赖氨酸氨基缀合制备的缀合物,以及通过聚合物与基因工程改造成蛋白质已知氨基酸序列的特定氨基酸位点的位点特异性缀合制备的缀合物。我们描述了对酶和几种亲和力识别蛋白的热敏随机偶联物的制备和性质。我们还制备了链霉亲和素与温度敏感的聚合物,pH敏感的聚合物和光敏感的聚合物的位点特异性缀合物。本文介绍了这些缀合物的制备及其许多引人入胜的应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号