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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Controlling human polymorphonuclear leukocytes motility using microfabrication technology
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Controlling human polymorphonuclear leukocytes motility using microfabrication technology

机译：使用微细加工技术控制人多形核白细胞运动

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摘要

We describe a new approach for controlling cell motility on a material surface. Transparent, photosensitive polyimide materials were used to fabricate physical structures on glass, cell motility was then followed over time using optical microscopy. Arrays of pillars and holes with 2 micron square, 4-#mu#im height (or depth) separated by 10 #mu#m were successfully patterned using photolithography. Neutrophils attached and spread on the smooth glass surface and surfaces with pillars. In contrast, cells were rounded and did not adhere to either smooth polyimide film or filmswith holes. The migration of neutrophils was much faster on holes than on polyimide surface, but it was significantly slower on pillars than on glass. These results suggest that physical patterning may be an effective tool to manipulate cell migration in the design of biomaterials for tissue engineering.
机译：我们描述了一种控制材料表面细胞运动的新方法。使用透明的光敏聚酰亚胺材料在玻璃上制作物理结构，然后使用光学显微镜随时间推移跟踪细胞运动性。使用光刻技术成功地图案化了2微米见方，高10微米的4微米高度（或深度）的支柱和孔阵列。中性粒细胞附着并散布在光滑的玻璃表面和带有柱子的表面上。相反，细胞是圆形的，没有粘附到光滑的聚酰亚胺薄膜或有孔的薄膜上。中性粒细胞在孔上的迁移要比聚酰亚胺表面快得多，但在柱子上的迁移要比在玻璃上的迁移慢得多。这些结果表明，在用于组织工程的生物材料设计中，物理图案化可能是操纵细胞迁移的有效工具。

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