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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Nanosized hydroxyapatite and other calcium phosphates: chemistry of formation and application as drug and gene delivery agents.
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Nanosized hydroxyapatite and other calcium phosphates: chemistry of formation and application as drug and gene delivery agents.

机译：纳米羟基磷灰石和其他磷酸钙：形成和用作药物和基因传递剂的化学。

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The first part of this review looks at the fundamental properties of hydroxyapatite (HAP), the basic mineral constituent of mammalian hard tissues, including the physicochemical features that govern its formation by precipitation. A special emphasis is placed on the analysis of qualities of different methods of synthesis and of the phase transformations intrinsic to the formation of HAP following precipitation from aqueous solutions. This serves as an introduction to the second part and the main subject of this review, which relates to the discourse regarding the prospects of fabrication of ultrafine, nanosized particles based on calcium phosphate carriers with various therapeutic and/or diagnostic agents coated on and/or encapsulated within the particles. It is said that the particles could be either surface-functionalized with amphiphiles, peptides, proteins, or nucleic acids or injected with therapeutic agents, magnetic ions, or fluorescent molecules. Depending on the additive, they could be subsequently used for a variety of applications, including the controlled delivery and release of therapeutic agents (extracellularly or intracellularly), magnetic resonance imaging and hyperthermia therapy, cell separation, blood detoxification, peptide or oligonucleotide chromatography and ultrasensitive detection of biomolecules, and in vivo and in vitro gene transfection. Calcium phosphate nanoparticles as carriers of therapeutic agents that would enable a controlled drug release to treat a given bone infection and at the same be resorbed in the body so as to regenerate hard tissue lost to disease are emphasized hereby as one of the potentially attractive smart materials for the modern medicine.
机译：这篇综述的第一部分着眼于羟磷灰石（HAP）的基本特性，羟磷灰石是哺乳动物硬组织的基本矿物成分，包括通过沉淀控制其形成的物理化学特征。特别强调的是分析不同合成方法的质量以及从水溶液中沉淀后HAP形成所固有的相变的质量。这是本综述的第二部分和主要主题的导论，涉及涉及基于磷酸钙载体的超细，纳米级颗粒的制造前景的论述，该颗粒上涂有多种治疗和/或诊断剂和/或包裹在颗粒内。据说这些颗粒可以用两亲物，肽，蛋白质或核酸进行表面功能化，也可以注入治疗剂，磁性离子或荧光分子。取决于添加剂，它们可随后用于多种应用，包括治疗剂的受控递送和释放（细胞外或细胞内），磁共振成像和热疗，细胞分离，血液排毒，肽或寡核苷酸色谱和超灵敏检测生物分子，以及体内外基因转染。特此强调，磷酸钙纳米颗粒作为治疗剂的载体，将使控释药物能够治疗给定的骨感染，并同时吸收到体内，从而再生出因疾病而失去的硬组织，这是一种潜在有吸引力的智能材料用于现代医学。

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