...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >PEGylated silica nanoparticles encapsulating multiple magnetite nanocrystals for high-performance microscopic magnetic resonance angiography.
【24h】

PEGylated silica nanoparticles encapsulating multiple magnetite nanocrystals for high-performance microscopic magnetic resonance angiography.

机译：聚乙二醇化的二氧化硅纳米颗粒包裹了多个磁铁矿纳米晶体，用于高性能显微磁共振血管造影。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A novel magnetic resonance (MR) angiographic method, 3DDeltaR2-mMRA (three dimensional and DeltaR2 based microscopy magnetic resonance angiography), is developed as a clinical diagnosis for depicting the function and structure of cerebral small vessels. However, the visibility of microvasculatures and the precision of cerebral blood volume calculation greatly rely on the transverse relaxivity and intravascular half-life of contrast agent, respectively. In this work, we report a blood pool contrast agent named H-FeO@SiO-PEG where multiple FeO nanocrystals are encapsulated in a thin silica shell to enhance the T-relaxivity (r = 342.8 mM(1) s(1)) and poly(ethylene glycol) (PEG) is employed to reduce opsonization and prolong circulation time of nanoparticles. Utilization of the newly developed H-FeO@SiO-PEG with a novel MR angiographic methodology, a high-resolution MR image of rat cerebral microvasculatures is successfully obtained.
机译：一种新型的磁共振（MR）血管造影方法3DDeltaR2-mMRA（基于三维和基于DeltaR2的显微镜磁共振血管造影）已被开发出来，作为描述脑小血管功能和结构的临床诊断方法。然而，微脉管系统的可视性和脑血流量的计算精度分别极大地取决于造影剂的横向弛豫性和血管内半衰期。在这项工作中，我们报告了一种名为H-FeO @ SiO-PEG的血池造影剂，其中多个FeO纳米晶体封装在薄硅壳中以增强T松弛度（r = 342.8 mM（1）s（1））和聚乙二醇（PEG）用于减少调理作用并延长纳米颗粒的循环时间。利用新开发的H-FeO @ SiO-PEG与新颖的MR血管造影方法，成功获得了大鼠脑微脉管系统的高分辨率MR图像。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号