...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Corrosion of Mg alloy AZ91D in the presence of living cells
【24h】

Corrosion of Mg alloy AZ91D in the presence of living cells

机译：活细胞存在下镁合金AZ91D的腐蚀

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Mg and Mg alloys are of interest for biodegradable implants as they readily corrode in biological fluids, and dissolved Mg ions are nontoxic. Even though it is well known that Mg dissolution leads to pH increase in the surroundings, the effect of the corrosion-induced alkalization on the biological environment has not been studied fn detail. We therefore explored the interactions between corrosion-induced pH increase and cell growth on Mg alloy AZ91D surface. Cell adhesion and spreading on the alloy surface is unimpeded initially. However, with time a large fraction of cells de-adhere. We attribute this to the observed increase of the pH in the cell culture medium in the process of alloy dissolution. Cytotoxicity tests with HeLa cells grown on glass surfaces confirm that cell death increases with increasing alkalinity of the cell culture medium. We also show that a the cells that adhere on the Mg alloy surface act as a corrosion-blocking surface layer. In consequence, a slower pH increase in the medium takes place when the alloy surface is covered with cells. Electrochemical impedance spec-troscopy measurements (EIS) verify that a cell layer slows down the corrosion process.
机译：Mg和Mg合金很容易在生物流体中腐蚀，并且可溶解的Mg离子无毒，因此对于可生物降解的植入物很重要。尽管众所周知，Mg的溶解会导致周围环境的pH值增加，但尚未详细研究腐蚀诱导的碱化对生物环境的影响。因此，我们探索了镁合金AZ91D表面腐蚀引起的pH值增加与细胞生长之间的相互作用。最初，细胞粘附和在合金表面的扩散不受阻碍。但是，随着时间的流逝，大部分细胞会脱离粘附。我们将其归因于合金溶解过程中细胞培养基中观察到的pH值增加。用生长在玻璃表面的HeLa细胞进行的细胞毒性测试证实，细胞死亡会随着细胞培养基碱度的增加而增加。我们还表明，粘附在Mg合金表面上的泡孔可作为防腐蚀表面层。结果，当合金表面被孔覆盖时，介质中的pH升高速度变慢。电化学阻抗谱测量（EIS）验证了细胞层可以减缓腐蚀过程。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号