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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Evaluation of host Inflammatory responses of p-ttiealeium phosphate bioceramics caused by calcium pyrophosphate impurity using a subcutaneous model
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Evaluation of host Inflammatory responses of p-ttiealeium phosphate bioceramics caused by calcium pyrophosphate impurity using a subcutaneous model

机译：使用皮下模型评估由焦磷酸钙杂质引起的对-磷酸铝钛生物陶瓷的宿主炎症反应

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摘要

Implantation of synthetic materials into body elicits inflammatory host responses that limit medical device integration and biological performance. Since the effective use of biomaterials in vivo requires good biocompatibility and bio-functionality, it is vital that we assess the inflammatory reactions provoked by various implanted biomaterials. In chemical precipitation of beta-tricalcium phosphate [beta-Ca_3(PO_4)_2, beta-TCP], the impurity of calcium pyrophosphate (Ca_2P_2O_7, CPP) will easily appear if the preparation conditions are not well controlled. To test the influences of CCP-impurity on the biocompatibility of the material, four groups of beta-TCP ceramic samples doped with 0.5-10 wt % of CCP impurity, and pure beta-TCP and CCP samples were fabricated and implanted in rat subcutaneous site for one, two, and four weeks. The host tissue responses to the ceramics were evaluated by histomorphometric analysis, and the results were compared with pure beta-TCPbioceramics. The results show that the CPP impurity can elicit and stimulate the inflammatory responses at the tissue/implant interface. Moreover, with the increase of CPP doping amount, the inflammation increases apparently. However, the pure beta-TCP bioceramics only present slight post-implantation inflammatory responses. The influence of the CPP doping on the inflammatory responses is mainly related to a microparticles release because of an insufficient sintering of beta-TCP by CPP doping. The microparticle release could be at the origin of local inflammation and cell/tissue damages. Therefore, to obtain perfect biocompatibility and high quality beta-TCP bioceramics, it is important to avoid and control the CPP impurity in the preparation of beta-TCP powders and bioceramics.
机译：将合成材料植入体内会引起炎症性宿主反应，从而限制医疗设备的整合和生物学性能。由于体内有效利用生物材料需要良好的生物相容性和生物功能性，因此至关重要的是，我们评估各种植入的生物材料引起的炎症反应。在β-磷酸三钙[β-Ca_3（PO_4）_2，β-TCP]的化学沉淀中，如果制备条件控制不当，焦磷酸钙的杂质（Ca_2P_2O_7，CPP）将容易出现。为了测试CCP杂质对材料生物相容性的影响，制作了四组掺有0.5-10 wt％CCP杂质的β-TCP陶瓷样品，并制备了纯β-TCP和CCP样品并将其植入大鼠皮下部位一，两个和四个星期。通过组织形态分析评估宿主组织对陶瓷的反应，并将结果与​​纯β-TCPbioceramics进行比较。结果表明，CPP杂质可引起和刺激组织/植入物界面的炎症反应。而且，随着CPP掺杂量的增加，炎症明显增加。然而，纯β-TCP生物陶瓷仅表现出轻微的植入后炎症反应。 CPP掺杂对炎症反应的影响主要与微粒释放有关，因为CPP掺杂对β-TCP的烧结不充分。微粒释放可能是局部炎症和细胞/组织损伤的起源。因此，为了获得完美的生物相容性和高质量的β-TCP生物陶瓷，在制备β-TCP粉末和生物陶瓷时避免和控制CPP杂质很重要。

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