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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Design and assessment of a wrapped cylindrical Ca-P AZ31 Mg alloy for critical-size ulna defect repair.
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Design and assessment of a wrapped cylindrical Ca-P AZ31 Mg alloy for critical-size ulna defect repair.

机译：设计和评估包裹的圆柱形Ca-P AZ31镁合金，用于尺骨尺骨缺损的修复。

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Recently, magnesium has been investigated as a promising bioresorbable orthopedic biomaterial. Its mechanical properties are very similar to natural bone, making it appropriate for load-bearing orthopedic fracture repair applications. However, significant hurdles remain regarding the design of practical implants and methods to control degradation and enhance biocompatibility. Although attempts have been made to hinder magnesium's rapid corrosion via alloying and coating, these studies have used solid monoliths. In an effort to reduce the amount of alloy used for implantation in a shape that mimics cortical bone shape, this study used a thin sheet of Mg AZ31 which was rolled into hollow cylindrical scaffolds. The scaffold was coated with different amounts of Ca-P; this implant demonstrated slowed corrosion in simulated body fluid (SBF) as well as enhanced biocompatibility for mesenchymal stem cells (MSC). In vivo implantation of magnesium alloy scaffold adjacent to the rat femur showed significant biointegration with further deposition of complex Mg-Ca phosphates/carbonates typical of natural bone. Finally, the implant was placed in a critical-size ulna defect in live rabbits, which lead to radiographic union and partial restoration of biomechanical strength in the defect. This study demonstrated that a thin sheet of coated Mg alloy that was spirally wrapped wound be a promising orthopedic biomaterial for bone repair.
机译：最近，已经研究了镁作为有前途的可生物吸收的骨科生物材料。它的机械性能与天然骨骼非常相似，使其非常适合承重的骨科骨折修复应用。但是，在设计实用的植入物和控制降解并增强生物相容性的方法方面，仍然存在重大障碍。尽管已经尝试通过合金化和涂层来阻止镁的快速腐蚀，但是这些研究使用了固体整体材料。为了减少用于仿制皮质骨形状的植入合金的数量，本研究使用了一块Mg AZ31薄钢板，将其轧制成空心圆柱形支架。支架涂有不同量的Ca-P。该植入物在模拟体液（SBF）中显示出减缓的腐蚀作用，并增强了间充质干细胞（MSC）的生物相容性。靠近大鼠股骨的镁合金支架的体内植入显示出显着的生物整合，并进一步沉积了天然骨典型的复合Mg-Ca磷酸盐/碳酸盐。最后，将植入物放置在活体兔的尺骨尺骨缺损处，这会导致放射照相联合并部分恢复缺损处的生物力学强度。这项研究表明，螺旋缠绕伤口的薄涂层镁合金是一种很有前途的骨修复生物材料。

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