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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Development of biodegradable polyurethane and bioactive glass nanoparticles scaffolds for bone tissue engineering applications.
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Development of biodegradable polyurethane and bioactive glass nanoparticles scaffolds for bone tissue engineering applications.

机译：用于骨组织工程应用的可生物降解的聚氨酯和生物活性玻璃纳米颗粒支架的开发。

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The development of polymer/bioactive glass has been recognized as a strategy to improve the mechanical behavior of bioactive glass-based materials. Several studies have reported systems based on bioactive glass/biopolymer composites. In this study, we developed a composite system based on bioactive glass nanoparticles (BGNP), obtained by a modified St?ber method. We also developed a new chemical route to obtain aqueous dispersive biodegradable polyurethane. The production of polyurethane/BGNP scaffolds intending to combine biocompatibility, mechanical, and physical properties in a material designed for tissue engineering applications. The composites obtained were characterized by structural, biological, and mechanical tests. The films presented 350% of deformation and the foams presented pore structure and mechanical properties adequate to support cell growth and proliferation. The materials presented good cell viability and hydroxyapatite layer formation upon immersion in simulated body fluid.
机译：聚合物/生物活性玻璃的开发已被认为是改善基于生物活性玻璃的材料的机械性能的策略。几项研究报告了基于生物活性玻璃/生物聚合物复合材料的系统。在这项研究中，我们开发了一种基于生物活性玻璃纳米颗粒（BGNP）的复合系统，该系统是通过改良的St？ber方法获得的。我们还开发了一条新的化学路线来获得水性分散可生物降解的聚氨酯。聚氨酯/ BGNP支架的生产旨在将生物相容性，机械和物理特性结合在一起，用于组织工程应用。通过结构，生物学和机械测试对获得的复合材料进行了表征。薄膜呈现350％的变形，泡沫呈现出足以支持细胞生长和增殖的孔结构和机械性能。当浸入模拟体液中时，该材料具有良好的细胞活力和羟基磷灰石层的形成。

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