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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Improving alginate-poly-L-ornithine-alginate capsule biocompatibility through genipin crosslinking.
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Improving alginate-poly-L-ornithine-alginate capsule biocompatibility through genipin crosslinking.

机译：通过genipin交联提高藻酸盐-聚-L-鸟氨酸-藻酸盐胶囊的生物相容性。

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摘要

DIABECELL? capsules comprise an inner core of alginate (Alg) coated with a polycationic polymer, poly-L-ornithine (PLO), designed as a stabilizing agent for strengthening the capsule wall, which is masked by an outer layer of biocompatible Alg. These polymeric microcapsules have demonstrated excellent mechanical properties and a reduction in hypoglycemia after tranplantation in human clinical trials; however, degradation of the outer Alg layer leaves the underlying layers of PLO exposed, which ultimately leads to reduced biocompatibility in vivo. Here we aim to improve capsule biocompatibility and to increase the hydrophilic properties of the capsule surface through chemical crosslinking/modification of the PLO layer using genipin. Fluorescence microscopy established crosslinking was limited to the layers of PLO. In vitro experiments confirmed islet viability and insulin release within chemically modified capsules over the course of a month and in vivo investigations demonstrated improved biocompatibility when comparing standard Alg/PLO/Alg capsules with genipin modified capsules.
机译：DIABECELL？胶囊包含藻酸盐（Alg）的内核，该内核涂有聚阳离子聚合物，聚L-鸟氨酸（PLO），被设计为稳定剂，用于增强胶囊壁，该壁被生物相容性Alg的外层掩盖。这些聚合微胶囊在人体临床试验中显示出优异的机械性能，并在移植后降低了低血糖症。但是，外部Alg层的降解使PLO的底层暴露在外，最终导致体内生物相容性降低。在这里，我们旨在通过使用genipin对PLO层进行化学交联/改性来改善胶囊的生物相容性并提高胶囊表面的亲水性。荧光显微镜建立的交联仅限于PLO层。体外实验证实了经过一个月的化学修饰后的胶囊在胰岛中的生存能力和胰岛素释放，而体内研究表明，将标准Alg / PLO / Alg胶囊与Genipin修饰的胶囊进行比较时，生物相容性得到了改善。

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