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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Effect of oxide layer modification of CoCr stent alloys on blood activation and endothelial behavior
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Effect of oxide layer modification of CoCr stent alloys on blood activation and endothelial behavior

机译：CoCr支架合金氧化层改性对血液活化和内皮行为的影响

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摘要

CoCr alloys, in particular MP35N and L605, are extensively used in biomedical implants, for example for coronary stents. In practice, these alloys present a moderately hydrophobic surface which leads to significant platelet adhesion and consequently to risk of early thrombosis or in-stent restenosis. Surface modification of biomedical implants is known to alter their biological performances. In this study we focused on the alteration of in vitro biological responses of human cells contacting CoCr surfaces with engineered oxide layers. XPS analysis was performed to determine the composition of the oxide layer of differently treated CoCr while the bulk properties were not modified. An extensive characterization of the surfaces was performed looking at surface roughness, wettability and charge. After static exposure to blood, strongly reduced platelet and increased polymorphonuclear neutrophil adhesion were observed on treated versus untreated surfaces. Comparisons of treated and untreated samples provide evidence for wettability being an important player for platelet adhesion, although multiple factors including surface oxide chemistry and charge might control polymorphonuclear neutrophil adhesion. The differently treated surfaces were shown to be equally suitable for endothelial cell proliferation. We herein present a novel approach to steer biological properties of CoCr alloys. By adjusting their oxide layer composition, substrates were generated which are suitable for endothelial cell growth and at the same time show an altered (reduced) blood contact activation. Such treatments are expected to lead to stents of highly reproducible quality with minimal thrombogenicity and in-stent restenosis, while maintaining rapid re-endothelialization after coronary angioplasty. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 629-640, 2015.
机译：CoCr合金，尤其是MP35N和L605，广泛用于生物医学植入物，例如冠状动脉支架。实际上，这些合金具有适度的疏水性表面，这导致明显的血小板粘附，因此有早期血栓形成或支架内再狭窄的风险。已知生物医学植入物的表面改性会改变其生物学性能。在这项研究中，我们专注于人类细胞接触CoCr表面与工程氧化层的体外生物学反应的变化。进行XPS分析以确定在不改变整体性能的情况下，经不同处理的CoCr氧化物层的组成。从表面粗糙度，润湿性和电荷来看，对表面进行了广泛的表征。静态暴露于血液后，在处理过的和未处理过的表面上均观察到血小板的强烈减少和多形核中性粒细胞粘附的增加。处理过的和未处理过的样品的比较提供了润湿性是血小板粘附的重要因素的证据，尽管包括表面氧化物化学和电荷在内的多种因素可能会控制多形核嗜中性粒细胞的粘附。显示不同处理的表面同样适用于内皮细胞增殖。我们在此提出了一种新颖的方法来控制CoCr合金的生物学性能。通过调节它们的氧化物层组成，产生了适合内皮细胞生长的底物，并且同时显示出改变的（减少的）血液接触活化。预期此类治疗将导致具有高度可复制质量的支架，具有最小的血栓形成性和支架内再狭窄，同时在冠状动脉血管成形术后保持快速的重新内皮化。 （c）2014 Wiley Periodicals，Inc. J Biomed Mater Res B部分：Appl Biomater，103B：629-640，2015。

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