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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Buccal adhesive nanofibers containing human growth hormone for oral mucositis
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Buccal adhesive nanofibers containing human growth hormone for oral mucositis

机译：含人类生长激素的口腔粘膜纳米纤维，用于口腔粘膜炎

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Due to a lack of proper drug carriers to deliver treatments for mucositis, many cancer patients suffer from oral mucositis caused by chemotherapy and radiotherapy. We prepared a double-layered electrospun nanofibrous sheets composed of Eudragit and chitosan to accelerate the healing rate of oral mucous ulcer. Human growth hormone (hGH) and Eudragit in a mixture of dimethylacetamide and ethanol were co-electrospun to nanofibrous sheets. The electrospun fibrous mat was subsequently layered with chitosan by a dip-coating method. Chitosan-layered sheets showed attenuated mass erosion while uncoated sheets were instantly melted at the physiological condition. The released hGH was trapped on the chitosan layer by the ionic interaction between positively charged chitosan and negatively charged hGH, and a large number of entrapped proteins remained on the SIS membrane due to the muco-adhesive properties of chitosan. hGH-incorporated sheets significantly increased proliferation of human dermal fibroblasts. In vivo study employing oral ulcers in dogs, the ulcers dressed with chitosan-layered sheets showed enhanced wound recovery and the chitosan layers on the sheet greatly assisted prolonged recovery. Therefore, chitosan-layered Eudragit nanofibrous sheets can be potentially applied to developing muco-adhesive wound dressing materials with pH-dependent drug release by adjusting the thickness of chitosan sheath on the sheets. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1396-1406, 2016.
机译：由于缺乏合适的药物载体来进行粘膜炎的治疗，许多癌症患者患有由化学疗法和放射疗法引起的口腔粘膜炎。我们制备了由Eudragit和壳聚糖组成的双层电纺纳米纤维片，可加快口腔粘膜溃疡的愈合速度。将人生长激素（hGH）和Eudragit在二甲基乙酰胺和乙醇的混合物中共电纺成纳米纤维片。随后通过浸涂法将电纺纤维垫与壳聚糖层合。壳聚糖层的片材显示出衰减的质量侵蚀，而未涂覆的片材在生理条件下立即融化。释放的hGH通过带正电的壳聚糖和带负电的hGH之间的离子相互作用而被捕获在壳聚糖层上，并且由于壳聚糖的粘膜粘附特性​​，大量截留的蛋白质保留在SIS膜上。结合hGH的床单显着增加了人类皮肤成纤维细胞的增殖。在犬中使用口腔溃疡进行的体内研究表明，穿戴有壳聚糖层状薄片的溃疡显示出伤口恢复增强，并且该薄片上的壳聚糖层大大有助于延长恢复期。因此，壳聚糖层的Eudragit纳米纤维片可潜在地用于通过调节片上壳聚糖护套的厚度来开发具有pH依赖性药物释放的粘膜粘附伤口敷料。 （c）2015 Wiley Periodicals，Inc. J Biomed Mater Res B部分：Appl Biomater，104B：1396-1406，2016。

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