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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >New synthetic absorbable polymers as BMP carriers: plastic properties of poly-D,L-lactic acid-polyethylene glycol block copolymers.
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New synthetic absorbable polymers as BMP carriers: plastic properties of poly-D,L-lactic acid-polyethylene glycol block copolymers.

机译：作为BMP载体的新型合成可吸收聚合物：聚D，L-乳酸-聚乙二醇嵌段共聚物的塑性。

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Bone morphogenetic proteins (BMPs) are biologically active molecules capable of eliciting new bone formation. In combination with biomaterials, these proteins can be used in a clinical setting as bone-graft substitutes to promote bone repair. To find new synthetic absorbable polymers with plastic nature that can be used as BMP-carrier materials, six types of poly-D,L-lactic acid-polyethylene glycol block copolymer (PLA-PEG) with various molecular weights of PLA and PEG were synthesized. These were PLA6, 500-PEG3,000 (P-1), PLA11,500-PEG3,000 (P-2), PLA17,500-PEG3,000 (P-3), PLA6,500-PEG1,000 (P-4), PLA15,000-PEG8,000 (P-5), and PLA8, 500-PEG1,000 (P-6). Fifty milligrams of these polymers was mixed with 0 microg (control) or 5, 10, or 20 microg of recombinant human BMP-2 (rhBMP-2). These pellets were implanted into the dorsal muscle pouches of 144 mice (six pellets consisting of the same polymer and dose of rhBMP-2 for a specific group). Three weeks after surgery, the pellets were harvested and examined by radiographic and histological methods. All P-1 pellets with 10 or 20 microg of rhBMP-2 showed bone formation with hematopoietic marrow and bony trabeculae, as did one third of those with 5 microg of rhBMP-2. The incidence of new bone formation with P-2 pellets or that of P-5 pellets was lower than that of P-1 pellets. No bone was formed in any other type of pellet. These results indicated that the PLA6, 500-PEG3,000 polymer with plastic properties was found to work well as a BMP carrier. Copyright 1999 John Wiley & Sons, Inc.
机译：骨形态发生蛋白（BMP）是能够引发新骨形成的生物活性分子。与生物材料结合使用时，这些蛋白质可在临床上用作骨移植替代品以促进骨修复。为了找到可以用作BMP载体材料的具有塑性的新型合成可吸收聚合物，合成了六种具有不同分子量PLA和PEG的聚D，L-乳酸-聚乙二醇嵌段共聚物（PLA-PEG） 。这些是PLA6、500-PEG3,000（P-1），PLA11,500-PEG3,000（P-2），PLA17,500-PEG3,000（P-3），PLA6,500-PEG1,000（P -4），PLA15,000-PEG8,000（P-5）和PLA8、500-PEG1,000（P-6）。将50毫克这些聚合物与0微克（对照）或5、10或20微克的重组人BMP-2（rhBMP-2）混合。将这些沉淀物植入144只小鼠的背肌袋中（六个沉淀物由相同的聚合物和特定组的rhBMP-2剂量组成）。手术后三周，收集沉淀物并通过射线照相和组织学方法检查。具有10或20微克rhBMP-2的所有P-1颗粒均显示具有造血骨髓和骨小梁的骨形成，具有5微克rhBMP-2的颗粒中的三分之一也是如此。 P-2颗粒或P-5颗粒的新骨形成发生率低于P-1颗粒。在任何其他类型的颗粒中均未形成骨骼。这些结果表明，发现具有塑性的PLA6、500-PEG3,000聚合物可以很好地用作BMP载体。版权所有1999 John Wiley＆Sons，Inc.

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