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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Influence of synthetic polymers on neutrophil migration in three-dimensional collagen gels
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Influence of synthetic polymers on neutrophil migration in three-dimensional collagen gels

机译：合成聚合物对三维胶原凝胶中嗜中性粒细胞迁移的影响

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In vitro studies of cell migration within three-dimensional polymeric materials are essential for under-standing cell behavior and for developing new biomedical materials. Human neutrophil motility was examined in hydrated collagen gels containing various synthetic polymers. Physical mixtures of collagen and certain water-soluble polymers formed stable gels that were good substrates for cell migration. Addition of either polyethylene glycol (PEG) or the pluronic~(TM) copolymer F68 did not change the morphological or mechanical properties of collagen gels, as determined by SEM and oscillatory rheometry; however, addition of either polymer significantly inhibited cell motility in both a modified 96-well chemotaxis chamber assay and a direct visual assay. Although the mechanism for this observed polymer inhibition of neutrophil migration is not yet clear, these results suggest that PEG and F68, two widely used biomedical polymers that are considered to be relatively "inert," may cause significant inhibition of cell motility.
机译：三维聚合材料中细胞迁移的体外研究对于了解细胞行为和开发新的生物医学材料至关重要。在含有各种合成聚合物的水合胶原凝胶中检查了人类嗜中性粒细胞的运动。胶原蛋白和某些水溶性聚合物的物理混合物形成稳定的凝胶，这些凝胶是细胞迁移的良好底物。如通过SEM和振荡流变法所确定的，添加聚乙二醇（PEG）或pluronic TM共聚物F68都没有改变胶原蛋白凝胶的形态或机械性能。然而，在改良的96孔趋化性室测定法和直接视觉测定法中，添加任何一种聚合物均显着抑制细胞运动。尽管这种观察到的聚合物抑制嗜中性粒细胞迁移的机制尚不清楚，但这些结果表明，PEG和F68，被认为是相对“惰性”的两种广泛使用的生物医学聚合物，可能会显着抑制细胞运动。

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