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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >In vivo evaluation of a novel alginate dressing.
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In vivo evaluation of a novel alginate dressing.

机译：新型藻酸盐敷料的体内评估。

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Alginate dressings are currently used in the management of epidermal and dermal wounds, and provide a moist environment that leads to rapid granulation and reepithelialization. However, a cytotoxic effect on proliferation of fibroblasts and residual material with inflammation in healing wounds have been reported recently. We have developed a new alginate dressing (AGA-100), which does not have an inhibitory effect on proliferation of fibroblasts. The purpose of this study was to evaluate the new alginate dressing with respect to wound healing in full- and partial-thickness pig wounds and with respect to biodegradation following implantation into rabbit muscle. Kaltostat and Sorbsan, both well-established commercial dressings, were used as control. The closure rate of full-thickness wounds treated with AGA-100 was significantly higher on day 15 compared with that with Kaltostat and Sorbsan. Reepithelialization rate of partial-thickness wounds treated with Sorbsan was statistically significantly lower on day 3 than those with the other two dressings. As to dressing debris remained in the healing wound, a large amount of foreign debris was noted in all the full-thickness wounds treated with Kaltostat or Sorbsan, while only about one-third of wounds treated with AGA-100 showed a little dressing debris. AGA-100 implanted into the muscle of rabbits was bioresorbed completely within 3 months. Therefore, dressing residue in AGA-100-treated full-thickness wounds might be fully absorbed in a few months. In conclusion, it is shown that our newly developed AGA-100 possesses superior properties compared with typical alginate dressings. Copyright 1999 John Wiley & Sons, Inc.
机译：海藻酸盐敷料目前用于表皮和真皮伤口的处理中，并提供了导致快速制粒和再上皮化的潮湿环境。然而，最近已经报道了在愈合伤口中对成纤维细胞的增殖和具有炎症的残留物质具有细胞毒性作用。我们开发了一种新的藻酸盐敷料（AGA-100），它对成纤维细胞的增殖没有抑制作用。这项研究的目的是评估新的藻酸盐敷料在全层和部分厚度猪伤口的伤口愈合以及植入兔肌肉后的生物降解方面。 Kaltostat和Sorbsan都是成熟的商业敷料，被用作对照。与Kaltostat和Sorbsan相比，在15天时用AGA-100处理的全层伤口的闭合率明显更高。在第3天，用Sorbsan治疗的部分较厚伤口的表皮再生率在统计学上显着低于其他两种敷料。至于愈合伤口中残留的敷料碎片，在用Kaltostat或Sorbsan处理的所有全层伤口中都发现了大量的异物碎片，而用AGA-100处理的伤口中只有约三分之一显示出少量的敷料碎片。植入兔肌肉的AGA-100在3个月内被完全生物吸收。因此，经AGA-100处理的全层伤口的敷料残留物可能会在几个月内被完全吸收。总之，表明我们新开发的AGA-100与典型的藻酸盐敷料相比具有优越的性能。版权所有1999 John Wiley＆Sons，Inc.

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