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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Carboxymethyl benzylamide sulfonate dextrans (CMDBS), a family of biospecific polymers endowed with numerous biological properties: a review.
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Carboxymethyl benzylamide sulfonate dextrans (CMDBS), a family of biospecific polymers endowed with numerous biological properties: a review.

机译：羧甲基苄基酰胺磺酸右旋糖酐（CMDBS），一种具有多种生物学特性的生物特异性聚合物：综述。

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The functionalized dextrans termed carboxymethyl benzylamide sulfonate dextran (CMDBS) represent a family encompassing a wide range of polymers. These soluble macromolecular compounds, which are substituted with specific chemical functional groups, are designed to interact with living systems. By analogy with glycosaminoglycan heparin, a natural highly charged anionic polysaccharide that exerts a variety of biological effects, we postulated that CMDBS compounds also possess binding sites capable of specific interactions with biological constituents, depending on the overall composition of the polymer. The synthesis and heparin-like properties of these CMDBS have been extensively investigated. Thus, it appears that dextran derivatives can mimic the action of heparin in regard to its interactions with antithrombin and serine proteases involved in blood coagulation. Other derivatives interact with various components of the immune system or with adhesive proteins such as fibronectin in modulating the proliferation of Staphylococcus aureus. Because they are able to stimulate wound healing in various in vivo models, these polysaccharides may also constitute a family of tissue repair agents because of their protecting and potentiating effects with heparin binding growth factors. Moreover, dextran derivatives in contact with cells such as endothelial cells, smooth muscle cells, or tumoral cells can affect both cell proliferation and metabolism. It appears that these bioactive polymers are also efficient tools to investigate the precise mechanism of action of individual biological activities by contrasting their mode of action to that of heparin. In addition to their numerous biological properties and biospecificity, functionalized dextrans are relatively simple to manufacture and exempt of donor contaminant, which make them attractive in a variety of clinical applications. Copyright 1999 John Wiley & Sons, Inc.
机译：称为羧甲基苄基酰胺磺酸右旋糖酐（CMDBS）的功能化右旋糖酐代表一个家族，涵盖了广泛的聚合物。这些被特定化学官能团取代的可溶性大分子化合物被设计为与生物系统相互作用。通过与糖胺聚糖肝素（一种发挥多种生物学作用的天然带负电荷的阴离子多糖）进行类比，我们推测CMDBS化合物还具有能够与生物成分发生特异性相互作用的结合位点，具体取决于聚合物的整体组成。这些CMDBS的合成和类肝素的性质已被广泛研究。因此，似乎葡聚糖衍生物可以模拟肝素在与凝血相关的抗凝血酶和丝氨酸蛋白酶的相互作用方面的作用。其他衍生物在调节金黄色葡萄球菌的增殖中与免疫系统的各种成分或与黏附蛋白（如纤连蛋白）相互作用。因为它们能够在各种体内模型中刺激伤口愈合，所以这些多糖由于具有肝素结合生长因子的保护和增强作用，因此也可以构成组织修复剂家族。而且，与细胞例如内皮细胞，平滑肌细胞或肿瘤细胞接触的右旋糖酐衍生物可以影响细胞增殖和代谢。似乎这些生物活性聚合物也是有效的工具，可通过将它们的作用方式与肝素进行对比来研究各个生物活性的确切作用机理。除了具有多种生物学特性和生物特异性外，功能化右旋糖酐的制造和释放供体污染物相对简单，这使其在多种临床应用中具有吸引力。版权所有1999 John Wiley＆Sons，Inc.

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