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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Plasmin degradation of fibrin coatings on synthetic polymer substrates.
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Plasmin degradation of fibrin coatings on synthetic polymer substrates.

机译：纤溶蛋白降解合成聚合物基质上的纤维蛋白涂层。

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The goal of this research was to evaluate the in vitro stability of fibrin coatings on polymeric materials in the presence of plasmin. Factor XIIIa-crosslinked and noncrosslinked fibrin layers were coated on three different polyurethane substrates: Corethane, Tegaderm, and a biodegradable polyurethane, PCL/HDI/Phe. Degradation assays indicated that crosslinking the fibrin coatings enhanced the stability of the coatings on both Tegaderm and PCL/HDI/Phe; however, the persistence of the coating on the woven Corethane was not influenced by crosslinking. Degradation assay results also showed that the fibrin coating on the Corethane was significantly less stable than the fibrin coatings on the Tegaderm and PCL/HDI/Phe films. The chromogenic substrate assay data showed crosslinking did not affect the specific plasmin activity on the coatings; therefore, the increased stability resulting from crosslinking was not achieved through a reduction of fibrinolysis. The plasmin activity on the coated Corethane samples was much greater than that on either of the coated flat wound dressing materials. The large surface area of Corethane, a porous woven vascular graft material, may have had a direct influence on the fibrinolysis of its coatings by providing a large number of tissue-type plasminogen activator (tPA) binding sites. A thin, crosslinked, fibrin-coated polyurethane provides a theoretically attractive biomaterial for use in a wound dressing application and should be subject to ongoing research. Copyright 1999 John Wiley & Sons, Inc.
机译：这项研究的目的是评估在存在纤溶酶的情况下，聚合物材料上纤维蛋白涂层的体外稳定性。将因子XIIIa交联的和非交联的纤维蛋白层涂覆在三种不同的聚氨酯基材上：Corethane，Tegaderm和可生物降解的聚氨酯PCL / HDI / Phe。降解试验表明，交联的纤维蛋白涂层增强了Tegaderm和PCL / HDI / Phe上涂层的稳定性。但是，交联不会影响编织的聚氨基甲酸酯上涂层的持久性。降解试验结果还表明，Corethane上的纤维蛋白涂层的稳定性明显低于Tegaderm和PCL / HDI / Phe膜上的纤维蛋白涂层。生色底物测定数据表明交联不影响涂层上的特定纤溶酶活性;因此，不能通过减少纤维蛋白溶解来实现因交联而增加的稳定性。涂覆的Corethane样品上的纤溶酶活性远高于两种涂覆的扁平伤口敷料材料上的纤溶酶活性。通过提供大量的组织型纤溶酶原激活剂（tPA）结合位点，多孔多孔血管移植材料Corethane的大表面积可能直接影响了其涂层的纤维蛋白溶解。薄的，交联的，纤维蛋白包被的聚氨酯为伤口包扎应用提供了理论上有吸引力的生物材料，应继续进行研究。版权所有1999 John Wiley＆Sons，Inc.

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