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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Cellular ingrowth and thickness changes in poly-L-lactide and polyglycolide matrices implanted subcutaneously in the rat.
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Cellular ingrowth and thickness changes in poly-L-lactide and polyglycolide matrices implanted subcutaneously in the rat.

机译：大鼠皮下植入的聚L-丙交酯和聚乙交酯基质的细胞向内生长和厚度变化。

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摘要

Highly porous matrices of poly-L-lactide (PL) and polyglycolide (PG), 24, 50, or 95 mg/cc in the form of 10 x 10 x 3 mm wafers, were implanted subcutaneously (two per rat) in the flanks of 8-12-week-old female Lewis rats (n = 120). Matrices were harvested, two rats per week, for 15 weeks and examined histologically. At weeks 1 and 2, a thin fibrous capsule was present and matrices showed capillary beds and host-cell infiltration along the implant margins. By week 4, the PL specimens had some arterioles while the PG specimens still had only capillary beds. At week 7, PL had well developed arterioles, venules, and capillaries while PG began to show modest vascular beds of capillaries only. In terms of cellular ingrowth, PL remained unchanged from 7 to 15 weeks. Giant cell formation was observed wherever polymer was present. There was a loss of thickness and cell mass for both matrices over time (PG > PL) despite initial host-cell ingrowth. As both polymers degraded and were absorbed, the ingrown cells mass regressed. There was little remaining PG at 15 weeks, leaving no trace of cells that previously had ingrown and no evidence of scar tissue.
机译：将24、50或95 mg / cc的聚L-丙交酯（PL）和聚乙交酯（PG）的高度多孔基质以10 x 10 x 3 mm晶片的形式皮下植入（每只大鼠两个） 8-12周大的雌性Lewis大鼠（n = 120）。每周两次收集基质，共15周，并进行组织学检查。在第1周和第2周，存在一个纤细的纤维囊，基质沿植入物边缘出现毛细血管床和宿主细胞浸润。到第4周，PL标本有一些小动脉，而PG标本仍然只有毛细血管床。在第7周，PL的小动脉，小静脉和毛细血管发育良好，而PG仅开始显示毛细血管适度的血管床。在细胞长入方面，PL在7至15周保持不变。无论在何处存在聚合物，均观察到巨细胞形成。尽管最初宿主细胞向内生长，但两种基质的厚度和细胞质量均随时间损失（PG> PL）。当两种聚合物降解并被吸收时，向内生长的细胞质量退化。 15周时剩余的PG很少，没有留下以前生长的细胞痕迹，也没有疤痕组织的迹象。

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