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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Decreased analyte transport through implanted membranes: Differentiation of biofouling from tissue effects
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Decreased analyte transport through implanted membranes: Differentiation of biofouling from tissue effects

机译：分析物通过植入膜的运输减少：生物污染与组织效应的区别

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摘要

Membrane biofouling and tissue changes in the foreign body response are known to cause detrimental reductions of analyte transport into implanted biosensors. The relative contribution of each phenomenon is unknown. Hollow fiber micro dialysis probes were employed to assess the effect of subcutaneous implantation on glucose flux through polymeric membranes in rats over 8 days and to differentiate the transport effects of biofouling versus tissue changes. Three commercially available membranes were examines: poly (ether sulfone) (PES), polyacrylonitrile (PAN), and polycarbonate (PC). As measured by glucose recovery (the ratio of micro dialysis glucose to blood glucose concentrations), transport though PES membranes was significantly less on day 2 than day 0 (39 percent, p<0.05) whereas PAN and PC showed no significant decreases in flux until day 8 (42 and 43 percent, respectively). Application of a transport model to glucose recovery data obtained before implantation in vivo and after explantation indicated that mass trans-port resistances originating from biofouling and tissue compartments increased between days 0 and 8. However, on average the biofouling layer adherent to the probe created substantially less resistance to glucose transport (12-24 percent of total) than did the tissue that surrounded the probe. These results suggested that future material developments for biosensors should be directed at understanding and modifying transport properties of tissues at the implant site.
机译：已知膜生物污染和异物反应中的组织变化会导致有害分析物减少进入被植入生物传感器的分析物。每种现象的相对贡献是未知的。中空纤维微透析探针用于评估皮下植入对大鼠在8天之内通过聚合物膜的葡萄糖通量的影响，并区分生物污损与组织变化的转运作用。检查了三种市售膜：聚（醚砜）（PES），聚丙烯腈（PAN）和聚碳酸酯（PC）。通过葡萄糖回收率（微透析葡萄糖与血糖浓度的比率）测量，第2天通过PES膜的运输明显少于第0天（39％，p <0.05），而PAN和PC的通量没有明显下降，直到第8天（分别为42％和43％）。将转运模型应用于体内植入前和植入后获得的葡萄糖回收数据表明，源自生物污损和组织区室的传质阻力在第0天到第8天之间增加。但是，平均而言，附着在探针上的生物污损层基本上产生了对葡萄糖转运的抵抗力比探针周围的组织低（占总数的12-24％）。这些结果表明，生物传感器的未来材料开发应针对理解和修改植入部位组织的运输特性。

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