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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Lateral augmentation of the mandible in minipigs with a synthetic nanostructured hydroxyapatite block
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Lateral augmentation of the mandible in minipigs with a synthetic nanostructured hydroxyapatite block

机译：用合成的纳米结构羟基磷灰石块体对小型猪的下颌骨进行侧向增强

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The purpose of this study was to evaluate biomaterial degradation and new bone formation after implantation of a nanostructured hydroxyapatite (HA) grafting block. Furthermore, physical characteristics of the biomaterial were measured. The biomaterial consists of nanostructured HA embedded in a porous matrix of silica (SiO 2) gel. The blocks with two different contents of silica (group A: 24 wt % and group B: 39 wt %) were fixed with titanium screws at the lateral aspect of the mandible of minipigs (n = 5). The specific surface areas of both blocks were measured using Brunauer-Emmett-Teller (BET) equation and mercury intrusion. In all animals, the wound healing was uneventful. After 5 weeks, the biomaterial percentage was 51.5% ?± 12.1% for group A and 33.2% ?± 5.9% for group B (p = 0.017). New bone formation accounted to 7.6% ?± 6.0% for group A and 15.3% ?± 8.3% for group B (p = 0.126) after 5 weeks. After 10 weeks, further resorption of the biomaterial led to percentages of 30.6% ?± 10.0% for group A and 12.1% ?± 6.7% for group B (p = 0.000). After 10 weeks, new bone formations were measured to be 34.1% ?± 10.8% in group A and 39.9% ?± 13.5% in group B (p = 0.383). The rate of degradation of the biomaterial is controlled by the composition of the material. A higher content of silica gel matrix leads to faster degradation of the biomaterial. The formation of new bone failed to show a significant difference between both groups.
机译：这项研究的目的是评估植入纳米结构羟基磷灰石（HA）接枝块后生物材料的降解和新骨的形成。此外，测量了生物材料的物理特性。该生物材料由嵌入二氧化硅（SiO 2）凝胶多孔基质中的纳米结构HA组成。将具有两种不同二氧化硅含量（A组：24 wt％和B组：39 wt％）的块用钛螺钉固定在小型猪下颌骨的侧面（n = 5）。使用Brunauer-Emmett-Teller（BET）方程和压汞法测量了两个块的比表面积。在所有动物中，伤口愈合良好。 5周后，A组的生物材料百分比为51.5％±12.1％，B组为33.2％±±5.9％（p ＝ 0.017）。 5周后，新的骨形成占A组的7.6％±6.0％和B组的15.3％±±8.3％（p = 0.126）。 10周后，生物材料的进一步吸收导致A组的百分比为30.6％±±10.0％，B组的百分比为12.1％±±6.7％（p = 0.000）。 10周后，A组新骨形成为34.1％±±10.8％，B组新骨形成为39.9％±±13.5％（p = 0.383）。生物材料的降解速率由材料的组成控制。硅胶基质的含量越高，生物材料的降解越快。新骨的形成未能显示两组之间的显着差异。

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