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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Biomimetic deposition of calcium phosphate minerals on the surface of partially demineralized dentine modified with phosphorylated chitosan.
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Biomimetic deposition of calcium phosphate minerals on the surface of partially demineralized dentine modified with phosphorylated chitosan.

机译：磷酸钙矿物质在磷酸钙化的脱乙酰壳多糖修饰的部分脱矿的牙质表面上的仿生沉积。

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摘要

The aim of this study is to remineralize partially demineralized dentine sections using phosphorylated chitosan (P-chi) based on mimicking the nucleating role of the phosphorylated noncollagenous proteins in the biomineralization of dentine. The surface of partially demineralized dentine sections, mainly composed of type I collagen, were modified by covalent immobilization of P-chi on the collagen surface. The dentine sections were subsequently put into remineralizing solution for remineralization, and then the remineralizing effect was investigated. The remineralization effect of this methodology was compared with that of fluoride. Moreover, the influence of surface properties of samples on remineralizing effect was investigated. The experimental results indicated that the effect of fluoride on remineralization of dentine was limited when residual crystals were lacking on the surface of partially demineralized dentine, whereas the covalent immobilization of P-chi can significantly induce deposition of calcium phosphate minerals on the surface of the partially demineralized dentine. This biomimetic methodology resulted in favorable surface properties (i.e., highly negative charge and low interfacial free energy between substrate and remineralizing medium) for crystal nucleation. Thus, P-chi can facilitate surface remineralization of dentine and thereby could find application in the minimally invasive management of dentine caries and dentine hypersensitivity.
机译：这项研究的目的是基于磷酸化的非胶原蛋白在牙本质生物矿化中的成核作用，使用磷酸化的脱乙酰壳多糖（P-chi）对部分脱矿质的牙本质切片进行再矿化。通过将P-chi共价固定在胶原蛋白表面上，对主要由I型胶原蛋白组成的部分脱矿质牙本质切片的表面进行了修饰。随后将牙本质切片放入再矿化溶液中进行再矿化，然后研究再矿化效果。将该方法的再矿化作用与氟化物进行了比较。此外，研究了样品的表面性质对再矿化效果的影响。实验结果表明，当部分去矿质的牙本质表面缺少残留的晶体时，氟化物对牙本质再矿化的作用受到限制，而P-chi的共价固定可明显诱导磷酸钙矿物质沉积在部分牙本质的表面。脱钙的牙本质。这种仿生方法学为晶体成核提供了有利的表面性质（即，高负电荷和底物与再矿化介质之间的低界面自由能）。因此，P-chi可促进牙本质的表面再矿化，从而可在牙本质龋的微创治疗和牙本质过敏中找到应用。

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