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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Inorganic coatings for cardiovascular stents: In vitro and in vivo studies
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Inorganic coatings for cardiovascular stents: In vitro and in vivo studies

机译：用于心血管支架的无机涂层：体外和体内研究

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摘要

The in-vitro and in-vivo biocompatibility of two oxides (TiO and ZrO) and diamond-like carbon (D) coated stents has been assessed and compared with uncoated stainless steel (St) stents. In vitro studies demonstrated that both fibrinogen adsorption and platelet adhesion were significantly higher on D coating compared to those on oxide coatings and uncoated stainless steel. In addition TiO and ZrO coatings showed evidence of a minor inflammatory response and more complete endothelialization of the aorta than that seen around D coated and uncoated St stents. The resulting neointimal growth in the aorta with TiO, ZrO, and D coated and uncoated St stents, measured 8 weeks after stenting (the ratio of the neointima in the stented artery to the non-stented artery) was 1.03 + 0.28, 0.85 + 0.36, 1.78 + 1.26, and 1.15 + 0.56, accordingly. From the data obtained it could be concluded that the increased neointima measured around D-coated stents, may be due to both, the inferior haemocompatibility of the diamond-like carbon coating and mechanical instability of D coating observed in an in vivo environment.
机译：已经评估了两种氧化物（TiO和ZrO）和类金刚石碳（D）涂层支架的体外和体内生物相容性，并将其与未涂层不锈钢（St）支架进行了比较。体外研究表明，与氧化物涂层和未涂层​​不锈钢相比，D涂层上的纤维蛋白原吸附和血小板粘附均显着更高。此外，与D涂层和未涂层​​的St支架相比，TiO和ZrO涂层显示出较小的炎症反应和主动脉内皮化更完全的证据。支架置入后8周测量（用TiO，ZrO和D涂层和未涂层​​的St支架在主动脉中产生的新内膜生长（支架内动脉与非支架内动脉中新内膜的比率）为1.03 + 0.28、0.85 + 0.36 ，1.78 + 1.26和1.15 + 0.56。从获得的数据可以得出结论，在D涂层支架周围测得的新内膜增加，可能是由于在体内环境中观察到的类金刚石碳涂层的血液相容性差和D涂层的机械不稳定性所致。

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