Cellular proliferation, cellular viability, and biocompatibility of HA-ZnO composites.

Saha N; Dubey AK; Basu B

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Cellular proliferation, cellular viability, and biocompatibility of HA-ZnO composites.

机译：HA-ZnO复合材料的细胞增殖，细胞活力和生物相容性。

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One of the important issues in the development of hydroxyapatite (HA)-based biomaterials is the prosthetic infection, which limits wider use of monolithic HA despite superior cellular response. Recently, we reported that ZnO addition to HA can induce bactericidal property. It is therefore important to assess how ZnO addition influences the cytotoxicity property and cell adhesion/proliferation on HA-ZnO composite surfaces in vitro. In the above perspective, the objective of this study is to investigate the cell type and material composition dependent cellular proliferation and viability of pressureless sintered HA-ZnO composites. The combination of cell viability data as well as morphological observations of cultured human osteoblast-like SaOS2 cells and mouse fibroblast L929 cells suggests that HA-ZnO composites containing 10 Wt % or lower ZnO exhibit the ability to support cell adhesion and proliferation. Both SaOS2 and L929 cells exhibit extensive multidirectional network of actin cytoskeleton and cell flattening on the lower ZnO containing (

机译：在基于羟基磷灰石（HA）的生物材料的开发中，重要的问题之一是假体感染，尽管细胞反应优异，但它限制了整体式HA的广泛使用。最近，我们报道了ZnO除HA外还可以诱导杀菌性能。因此，重要的是要评估ZnO的添加如何在体外影响HA-ZnO复合材料表面的细胞毒性和细胞粘附/增殖。从以上观点出发，本研究的目的是研究无压烧结HA-ZnO复合材料的细胞类型和材料组成，取决于细胞的增殖和活力。细胞活力数据以及培养的人成骨样SaOS2细胞和小鼠成纤维细胞L929细胞的形态学观察的结合表明，含有10 Wt％或更低ZnO的HA-ZnO复合材料具有支持细胞粘附和增殖的能力。 SaOS2和L929细胞均表现出广泛的肌动蛋白细胞骨架多方向网络，并且在含ZnO含量较低（<= 10 Wt％）的HA-ZnO复合材料上细胞扁平化。体外结果表明，如使用MTT生化分析所评估的，ZnO含量的变化如何显着影响细胞活力。同样，关键的统计分析表明，ZnO的添加需要仔细调整以确保良好的体外细胞相容性。分析了生物学特性差异的根本原因。提示表面润湿性以及ZnO的溶解都有助于观察到细胞活力和增殖的差异。

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《Journal of biomedical materials research. Part B, Applied biomaterials.》 |2012年第1期|共9页
作者
Saha N; Dubey AK; Basu B;
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Cellular proliferation, cellular viability, and biocompatibility of HA-ZnO composites.

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