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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Highly packed and aligned fluoride substituted hydroxyapatite via a surfactant-free process.
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Highly packed and aligned fluoride substituted hydroxyapatite via a surfactant-free process.

机译：通过无表面活性剂工艺，高度填充和排列的氟化物取代的羟基磷灰石。

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Biomolecules and surfactants are believed to be the key factors for reconstruction of tooth enamel and preparation of fluoride hydroxyapatite coating with enamel-like structure on dental implants. We have developed an alternative surfactant-free biomimetic method to stimulate growth of fluoride substituted hydroxyapatite coatings with highly packed and aligned structure on metallic substrates. Oxidized titanium plates were chosen as the substrates. The biomimetic fluoride hydroxyapatite was prepared by immersing the pretreated Ti plates into the phosphate-buffered solution with Ca(2+), H(2)PO(4)(-), HPO(4)(2-), and F(-). The pH value was controlled at 7.4 at the beginning. Every titanium plate (10 mm x 10 mm x 1 mm) was soaked into 20 mL of ion doped phosphate buffered solution in sealed plastic bottles, kept at 37 degrees C or 60 degrees C without stirring for time periods of 1 day to 2 weeks. After immersion, the samples were removed from the solution, rinsed with deionized water and allowed to dry in air. The fluoride substituted hydroxyapatite layer, composed of needle-like crystallites with the diameter of 10-20 nm, was well-organized and tightly packed. XRD results showed a sharper and stronger (002) peak, which could be used to explain that there was a preferable orientation along the c axis. The coating could be reconstructed on the former layer if the mineralization process was repeated, and the structure of the coating could be preserved. The method could be used to construct well organized fluoride substitute hydroxyapatite coating on metal implants.
机译：人们认为生物分子和表面活性剂是重建牙釉质和在牙植入物上制备具有牙釉质样结构的氟化物羟基磷灰石涂层的关键因素。我们已经开发出了一种替代性的无表面活性剂仿生方法，以刺激在金属基材上具有高度堆积和排列结构的氟化物取代的羟基磷灰石涂层的生长。选择氧化钛板作为基材。通过将预处理的Ti板浸入具有Ca（2 +），H（2）PO（4）（-），HPO（4）（2-）和F（-）的磷酸盐缓冲溶液中来制备仿生氟化物羟基磷灰石）。开始时将pH值控制在7.4。将每个钛板（10mm×10mm×1mm）浸入密封塑料瓶中的20mL离子掺杂的磷酸盐缓冲溶液中，保持在37℃或60℃，而无需搅拌1天至2周的时间。浸没后，将样品从溶液中取出，用去离子水冲洗，然后在空气中干燥。由直径为10到20 nm的针状微晶组成的氟化物取代的羟基磷灰石层组织良好且紧密堆积。 XRD结果显示出一个更锐利和更强的（002）峰，可以用来解释沿c轴有一个较好的方向。如果重复矿化过程，则可以在前一层上重建涂层，并可以保留涂层的结构。该方法可用于在金属植入物上构建组织良好的氟化物替代羟基磷灰石涂层。

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