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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Comparative evaluation of three calcium phosphate synthetic block bone graft materials for bone regeneration in rabbit calvaria.
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Comparative evaluation of three calcium phosphate synthetic block bone graft materials for bone regeneration in rabbit calvaria.

机译：三种磷酸钙合成嵌段骨移植材料对兔颅骨骨再生的比较评估。

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摘要

Various synthetic materials were developed to be used for implant dentistry and periodontal treatments. Among the various synthetic bone substitutes, calcium phosphate ceramics have been extensively investigated because their mineral chemistry resembles that of human bone. We evaluated the regeneration of three calcium phosphate synthetic block bone grafts in rabbit calvarial noncritical size defects. Four 8-mm-diameter defects were created in each rabbit (N = 10). Three defects, hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP), and biphasic calcium phosphate (BCP), were randomly filled with one of three fabricated synthetic block bone graft materials. The fourth defect was filled with blood clots. Specimens were harvested at 4 and 8 weeks postsurgery. Histological and histometrical findings indicated that all three calcium phosphate block bone graft materials were able to maintain space significantly better than the control group at both 4 and 8 weeks. In the BCP group, the amount of newly formed bone was increased more than for the other groups. Additionally, β-TCP showed a large resorption of graft materials after 4 weeks postsurgery, while there were only small resorption for HA and BCP. ? 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
机译：已开发出各种合成材料用于种植牙和牙周治疗。在各种合成的骨替代物中，磷酸钙陶瓷的矿物化学类似于人骨，因此已被广泛研究。我们评估了兔颅骨非关键性大小缺损中三种磷酸钙合成块状骨移植物的再生。在每只兔子中创建了四个直径为8毫米的缺陷（N = 10）。用三种人造合成块状骨移植材料之一随机填充了三个缺陷，即羟基磷灰石（HA），β-磷酸三钙（β-TCP）和双相磷酸钙（BCP）。第四个缺陷充满了血块。术后4周和8周收集标本。组织学和组织学检查结果表明，所有三种磷酸钙块状骨移植材料在第4周和第8周都能够比对照组明显更好地保持空间。在BCP组中，新形成的骨骼数量比其他组增加了更多。另外，术后4周，β-TCP对移植物的吸收较大，而HA和BCP的吸收较小。 ？ 2012 Wiley Periodicals，Inc. J Biomed Mater Res B部分：Appl Biomater，2012年。

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