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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >In vitro evaluation of dentinal hydraulic conductance and tubule sealing by a novel calcium-phosphate desensitizer.
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In vitro evaluation of dentinal hydraulic conductance and tubule sealing by a novel calcium-phosphate desensitizer.

机译：新型磷酸钙脱敏剂对牙本质水力传导和小管封闭的体外评估。

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摘要

In the current trend of materials used for dentin hypersensitivity treatment, calcium-phosphate-containing desensitizers are expected to have advantages in oral environment. A newly formulated desensitizer containing tetracalcium phosphate and dicalcium phosphate anhydrous (CPD-100) was evaluated in comparison to oxalate containing desensitizer (SS) regarding permeability reduction (PR%) by measuring hydraulic conductance on the etched dentin discs in vitro. CPD-100 exhibited mean PR% of 91%, which significantly increased to 98% after immersion in artificial saliva (AS) for 4 weeks (p < 0.001), while SS showed a significant decrease from 99% to 93% (p < 0.01). SEM observation showed newly formed crystallites on CPD-100 treated dentin, which did not exist in SS treated dentin after AS immersion, suggesting that calcium oxalate inhibited formation of new calcium-phosphate minerals. Five-minute acid challenge did not significantly affect PR% of dentin treated by any of the desensitizers. The energy dispersive X-ray spectroscopy (EDS) analysis indicated that the formed layer of CPD-100 were minerals with similar Ca/P ratio to hydroxyapatite. In conclusion, the newly developed calcium-phosphate desensitizer has the potential to exhibit long-term stability in the oral environment, owing to its chemical properties that promote the crystal growth in salivary fluid.
机译：在用于牙本质增敏治疗的材料的当前趋势中，预期含磷酸钙的脱敏剂在口腔环境中具有优势。通过在体外测量蚀刻的牙本质椎间盘上的水力传导率，与含草酸盐的脱敏剂（SS）相比，评估了一种新配制的含有磷酸四钙和无水磷酸二钙的脱敏剂（CPD-100）。 CPD-100的平均PR％为91％，浸入人工唾液（AS）4周后显着增加至98％（p <0.001），而SS则从99％显着下降至93％（p <0.01） ）。 SEM观察表明，经CPD-100处理的牙本质上新形成的微晶，在AS浸泡后在SS处理的牙本质中不存在，表明草酸钙抑制了新的磷酸钙矿物质的形成。五分钟的酸刺激并没有显着影响通过任何脱敏剂治疗的牙本质的PR％。能量色散X射线光谱（EDS）分析表明，CPD-100形成的层是具有与羟基磷灰石相似的Ca / P比的矿物。总之，由于其化学特性可促进唾液中晶体的生长，因此新开发的磷酸钙脱敏剂具有在口腔环境中显示长期稳定性的潜力。

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