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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Synthesis of multifunctional bioresponsive polymers for the management of chronic wounds
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Synthesis of multifunctional bioresponsive polymers for the management of chronic wounds

机译：合成多功能生物响应性聚合物以治疗慢性伤口

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Novel multifunctional bioresponsive gelatin and alginate based hydrogels with in-built antioxidant regenerating system and antimicrobial properties were successfully synthesized. These hydrogels are based on the versatile reactions catalyzed by cellobiose dehydrogenase (CDH). CDH uses cellobiose and cello-oligosacharides as electron donors to reduce oxidized phenolic antioxidants, quinones, or molecular oxygen to H2O2 (a well-known antimicrobial agent). The antioxidant regenerating system consisting of CDH and cellobiose increased the ability of catechol to quench nitric oxide (NO), superoxide (O2 -) and hydroxyl radicals (OH ?) in solution and when incorporated into hydrogels. The CDH loaded into the hydrogels free of oxidized phenolic antioxidants and quinones reduced molecular to H2O2 resulting in the complete inhibition of the growth of Stapylococcus aeureus, Bacillus subtilis, Pseudomonas putida, Escherichia coli and Cellulomonasmicrobium cellulans. This study therefore presents a new concept for synthesizing multifunctional bioresponsive chronic wound dressing polymers with in-built continuous antioxidant system able to continuously quench [reactive oxygen species (ROS) and reactive nitrogen species (RNOS)], and antimicrobial properties able to prevent microbial colonization of wound.
机译：成功地合成了具有内置抗氧化剂再生系统和抗菌特性的新型多功能生物响应明胶和藻酸盐基水凝胶。这些水凝胶是基于纤维二糖脱氢酶（CDH）催化的通用反应。 CDH使用纤维二糖和纤维寡糖作为电子供体，将氧化的酚类抗氧化剂，醌或分子氧还原为H2O2（一种著名的抗菌剂）。由CDH和纤维二糖组成的抗氧化剂再生系统提高了邻苯二酚淬灭溶液中以及掺入水凝胶中的一氧化氮（NO），超氧化物（O2--）和羟基自由基（OH +）的能力。 CDH加载到不含氧化酚类抗氧化剂和醌的水凝胶中时，分子还原为H2O2，从而完全抑制了金黄色葡萄球菌，枯草芽孢杆菌，恶臭假单胞菌，大肠杆菌和纤维单胞菌纤维素的生长。因此，本研究提出了一种新的概念，用于合成多功能生物响应性慢性伤口敷料聚合物，该聚合物具有内置的连续抗氧化剂系统，能够连续淬灭[活性氧（ROS）和活性氮（RNOS）]，并具有能够防止微生物定殖的抗菌特性伤口

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