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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Drug delivery from hydroxyapatite-coated titanium surfaces using biodegradable particle carriers.
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Drug delivery from hydroxyapatite-coated titanium surfaces using biodegradable particle carriers.

机译：使用可生物降解的颗粒载体从羟基磷灰石涂层的钛表面递送药物。

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The goal of this study was to develop a functional titanium (Ti) implant loaded with bioactive molecules using biodegradable polymeric particles as drug delivery carrier for dental applications. In this study, dexamethasone (DEX)-loaded poly(lactic-co-glycolic acid) (PLGA) particles were electrostatically immobilized on a Ti disc surface coated with hydroxyapatite (HA) nanocrystals using a low temperature high speed collision (LTHSC) method. Resorbable blasting media (RBM) Ti discs (S1), HA-Ti discs (S2), and HA-Ti discs treated with DEX-loaded PLGA particles (S3) were fabricated in this study as sample discs. To facilitate surface immobilization, PLGA particles were coated with polyethyleneimine (PEI) to produce a positive surface charge. This modification of PLGA particle surfaces, allowed DEX-loaded PLGA particles to be immobilized on negatively charged S2 disc surface. It was found that DEX-loaded PLGA particles were well dispersed and immobilized onto the S3 disc surfaces. Release profile studies of DEX from S3 discs in a 4-week immersion study indicated an initial burst release followed by sustained release. In vitro evaluation of bone marrow derived mesenchymal stem cells (BMSCs) cultured for 1 and 2 weeks on S3 discs showed greater BMSC differentiation than on S1 or S2 discs, demonstrating that this innovative delivery platform potently induced BMSC differentiation in vitro, and suggesting that it could be exploited for stem cell therapy purposes or to enhance in vivo osteogenesis. In addition, the results of the present study shows that various bioactive molecules that promote bone regeneration can be efficiently incorporated onto HA-Ti surfaces using biodegradable polymeric particles.
机译：这项研究的目的是开发一种功能强大的钛（Ti）植入物，该植入物使用可生物降解的聚合物颗粒作为牙科应用的药物输送载体，负载了生物活性分子。在这项研究中，使用低温高速碰撞（LTHSC）方法将地塞米松（DEX）负载的聚乳酸-乙醇酸共聚物（PLGA）颗粒静电固定在涂有羟基磷灰石（HA）纳米晶体的Ti圆盘表面上。在本研究中，将可吸收的抛丸介质（RBM）Ti圆盘（S1），HA-Ti圆盘（S2）和经过DEX加载的PLGA颗粒（S3）处理的HA-Ti圆盘制成样本圆盘。为了促进表面固定，将PLGA颗粒涂上聚乙烯亚胺（PEI）以产生正表面电荷。 PLGA粒子表面的这种修饰使装载DEX的PLGA粒子固定在带负电荷的S2光盘表面上。发现载有DEX的PLGA颗粒被充分分散并固定在S3盘表面上。在4周的浸入式研究中，DEX从S3光盘的释放曲线研究表明，最初的爆炸释放是持续释放。在S3盘上培养1周和2周的骨髓源间充质干细胞（BMSC）的体外评估显示，与在S1或S2盘上相比，BMSC的分化程度更高，表明该创新的递送平台在体外可有效诱导BMSC分化，并提示可用于干细胞治疗目的或增强体内成骨作用。另外，本研究的结果表明，使用可生物降解的聚合物颗粒可以将各种促进骨骼再生的生物活性分子有效地掺入HA-Ti表面。

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