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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >PMMA-hydroxyapatite composite material retards fatigue failure of augmented bone compared to augmentation with plain PMMA: In vivo study using a sheep model
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PMMA-hydroxyapatite composite material retards fatigue failure of augmented bone compared to augmentation with plain PMMA: In vivo study using a sheep model

机译：与普通PMMA增强相比，PMMA-羟基磷灰石复合材料可延缓增强骨的疲劳破坏：使用绵羊模型的体内研究

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Polymethylmethacrylate (PMMA) is the most commonly used void filler for augmentation of osteoporotic vertebral fracture, but the differing mechanical features of PMMA and osteoporotic bone result in overload and failure of adjacent bone. The aim of this study was to compare fatigue failure of bone after augmentation with PMMA-nanocrystalline hydroxyapatite (HA) composite material or with plain PMMA in a sheep model. After characterization of the mechanical properties of a composite material consisting of PMMA and defined amounts (10,20, and 30% volume fraction) of HA, the composite material with 30% volume fraction HA was implanted in one distal femur of sheep; plain PMMA was implanted in the other femur. Native non-augmented bone served as control. Three and 6 months after implantation, the augmented bone samples were exposed to cyclic loading and the evolution of damage was investigated. The fatigue life was highest for the ovine native bone and lowest for bone-PM MA specimens. Bone-composite specimens showed significantly higher fatigue life than the respective bone-PMMA specimens in both 3- and 6-month follow-up groups. These results suggest that modification of mechanical properties of PMMA by addition of HA to approximate those of cancellous bone retards fatigue failure of the surrounding bone compared to augmented bone with plain PMMA. (C) 2014 Wiley Periodicals, Inc.
机译：聚甲基丙烯酸甲酯（PMMA）是最常用的填充骨质疏松性椎体骨折的空隙填充物，但是PMMA和骨质疏松性骨的不同机械特性会导致相邻骨的过载和衰竭。这项研究的目的是在绵羊模型中比较使用PMMA-纳米晶羟基磷灰石（HA）复合材料或使用普通PMMA增强后的骨骼疲劳失效。在表征了由PMMA和规定量（10,20和30％体积分数）的HA组成的复合材料的机械性能后，将具有30％体积分数HA的复合材料植入了一只羊的股骨远端。普通PMMA植入另一股股骨。天然非增强骨作为对照。植入后三个月和六个月，将增强的骨样品暴露于循环载荷下，并研究损伤的演变。绵羊原生骨骼的疲劳寿命最高，而骨骼-PM MA标本的疲劳寿命最低。在3个月和6个月的随访组中，骨复合材料样本的疲劳寿命均显着高于各自的PMMA骨样本。这些结果表明，与添加普通PMMA的增强骨相比，通过添加HA使其接近松质骨，可以改善PMMA的机械性能，从而延缓了周围骨骼的疲劳破坏。 （C）2014威利期刊公司

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