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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Histological and compositional evaluations of three types of calcium phosphate cements when implanted in subcutaneous tissue immediately after mixing.
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Histological and compositional evaluations of three types of calcium phosphate cements when implanted in subcutaneous tissue immediately after mixing.

机译：混合后立即将三种类型的磷酸钙水泥植入皮下组织的组织学和组成评估。

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To evaluate the soft tissue response of calcium phosphate cement (CPC), consisting of an equimolar mixture of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA) under conditions close to those encountered in actual surgical procedures, we implanted three types of CPC [conventional CPC (c-CPC), fast-setting CPC (FSCPC), and antiwashout type FSCPC (aw-FSCPC; formerly called nondecay type FSCPC or nd-FSCPC)] subcutaneously in the abdomens of rats immediately (1 min) after mixing. At 1 week after surgery, histological examination and compositional analysis were performed using light microscopy and powder X-ray diffraction (XRD), respectively. The implanted c-CPC was crumbled completely, whereas FSCPC and aw-FSCPC retained their shape. Large vesicles containing copious inflammatory effusion were subcutaneously formed around the c-CPC. Histologically, many foreign-body giant cells were collected around the c-CPC, and moderate inflammatory cell infiltration was observed at 1 week after surgery. In contrast, the FSCPC and aw-FSCPC were covered with a thin layer of granulation tissue that included few giant cells and presented slight inflammatory cell infiltration, and no effusion was observed. The XRD analysis of the c-CPC revealed the presence of some unreacted DCPA even 1 week after implantation, whereas almost no DCPA was found in the FSCPC or aw-FSCPC. In conclusion, it was found that CPC does not always show excellent tissue response. When c-CPC is implanted subcutaneously in rats immediately after mixing, it fails to set and causes a severe inflammatory response. Therefore, the type of CPC should be chosen according to the clinical particulars. CPC should be used in a manner that assures its setting reaction. We recommend the use of FSCPC and aw-FSCPC for surgical applications, such as orthopedics, plastic and reconstructive surgery, and oral and maxillofacial surgery, where the cement might otherwise crumble due to the pressure before setting.
机译：为了评估由磷酸四钙（TTCP）和无水磷酸二钙（DCPA）的等摩尔混合物组成的磷酸钙水泥（CPC）在接近实际外科手术的条件下的软组织反应，我们植入了三种类型的CPC [混合后立即（1分钟）皮下在大鼠腹部皮下注射常规的CPC（c-CPC），快速凝固的CPC（FSCPC）和抗冲洗型FSCPC（aw-FSCPC;以前称为非衰变型FSCPC或nd-FSCPC）。术后1周，分别使用光学显微镜和粉末X射线衍射（XRD）进行组织学检查和成分分析。植入的c-CPC完全破裂，而FSCPC和aw-FSCPC保持其形状。在c-CPC周围皮下形成含有大量炎性积液的大囊泡。组织学上，在c-CPC周围收集到许多异物巨细胞，并且在手术后1周观察到中等程度的炎症细胞浸润。相反，FSCPC和aw-FSCPC覆盖着一层肉芽组织薄层，其中几乎没有巨细胞，并有轻微的炎性细胞浸润，未观察到积液。对c-CPC的XRD分析表明，即使在植入后1周，仍存在一些未反应的DCPA，而在FSCPC或aw-FSCPC中几乎未发现DCPA。总之，发现CPC并不总是显示出出色的组织反应。混合后立即将c-CPC皮下植入大鼠体内时，它无法凝固并引起严重的炎症反应。因此，应根据临床情况选择CPC的类型。 CPC的使用应确保其固化反应。我们建议在外科应用中使用FSCPC和aw-FSCPC，例如整形外科，整形和重建外科以及口腔和颌面外科，在这些情况下，由于凝固前的压力，水泥可能会碎裂。

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