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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Nickel release from orthodontic arch wires and cellular immune response to various nickel concentrations.
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Nickel release from orthodontic arch wires and cellular immune response to various nickel concentrations.

机译：正畸弓丝中的镍释放以及对各种镍浓度的细胞免疫反应。

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AIMS: Results from two previous clinical studies suggested that exposure to high nickel-containing orthodontic arch wires may induce hypersensitivity in certain individuals. The purpose of this study was to measure the amount of nickel released from three types of nickel-containing arch wires into a synthetic saliva in vitro, and determine if the concentrations were sufficient to elicit either cytotoxic (trypan blue exclusion test) or stimulatory (MTT test) responses in human peripheral blood mononuclear cells (PBMCs) derived from nickel-sensitive and nickel-nonsensitive individuals. PBMCs were exposed to five concentrations of nickel sulfate solutions ranging from 0-29 ppm, and results were compared, particularly at concentrations obtained from nickel release experiments. FINDINGS: The amount of nickel released into synthetic saliva ranged from 0.4-4.1 ppb. Wires subjected to a combination of soaking and cyclic straining released significantly more nickel than those that were soaked only (p
机译：目的：两项先前的临床研究结果表明，暴露于高含镍正畸弓丝可能会导致某些人过敏。这项研究的目的是在体外测量从三种类型的含镍弓丝释放到合成唾液中的镍的量，并确定其浓度是否足以引起细胞毒性（锥虫蓝排除试验）或刺激性（MTT）测试）来自对镍敏感和对镍不敏感的个体的人外周血单核细胞（PBMC）中的反应。将PBMC暴露于0-29 ppm的五种浓度的硫酸镍溶液中，并对结果进行比较，尤其是在从镍释放实验中获得的浓度下。结果：合成唾液中释放的镍量为0.4-4.1 ppb。与均热和循环应变相结合的金属丝释放出的镍比仅经过浸泡的金属释放的镍要多得多（p

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