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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Mechanical properties of human autologous tubular connective tissues (human biotubes) obtained from patients undergoing peritoneal dialysis
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Mechanical properties of human autologous tubular connective tissues (human biotubes) obtained from patients undergoing peritoneal dialysis

机译：从接受腹膜透析的患者获得的人体自体管状结缔组织（人体生物管）的力学性能

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Completely autologous in vivo tissue-engineered connective tissue tubes (Biotubes) have promise as arterial vascular grafts in animal implantation studies. In this clinical study of patients undergoing peritoneal dialysis (PD) (n=11; age: 39-83 years), we evaluated human Biotubes' (h-Biotubes) mechanical properties to determine whether Biotubes with feasibility as vascular grafts could be formed in human bodies. We extracted PD catheters, embedded for 4-47 months, and obtained tubular connective tissues as h-Biotubes (internal diameter: 5 mm) from around the catheter' silicone tubular parts. h-Biotubes were composed mainly of collagen with smooth luminal surfaces. The average wall thickness was 278 +/- 178 m. No relationship was founded between the tubes' mechanical properties and patients' ages or PD catheter embedding periods statistically. However, the elastic modulus (2459 +/- 970 kPa) and tensile strength (623 +/- 314 g) of h-Biotubes were more than twice as great as those from animal Biotubes, formed from the same PD catheters by embedding in the beagle subcutaneous pouches for 1 month, or beagle arteries. The burst strength (6338 +/- 1106 mmHg) of h-Biotubes was almost the same as that of the beagle thoracic or abdominal aorta. h-Biotubes could be formed in humans over a 4-month embedding period, and they satisfied the mechanical requirements for application as vascular grafts. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1431-1437, 2016.
机译：完全自体的体内组织工程结缔组织管（Biotubes）在动物植入研究中有望作为动脉血管移植物。在这项针对腹膜透析（PD）患者（n = 11;年龄：39-83岁）的临床研究中，我们评估了人类Biotubes（h-Biotubes）的力学性能，以确定是否可以在体内形成具有血管移植可行性的Biotubes。人体。我们提取了PD导管，植入了4-47个月，并从导管的硅胶管状部分周围获得了h-Biotubes管状结缔组织（内径：5 mm）。 h-Biotubes主要由具有光滑腔表面的胶原蛋白组成。平均壁厚为278 +/- 178m。在统计学上，管的机械性能与患者的年龄或PD导管的包埋时间之间没有关系。然而，h-Biotubes的弹性模量（2459 +/- 970 kPa）和抗张强度（623 +/- 314 g）大于动物Biotubes的两倍，后者是由相同的PD导管通过嵌入beagle皮下囊囊放置1个月或beagle动脉。 h-Biotubes的破裂强度（6338 +/- 1106 mmHg）与小猎犬的胸主动脉或腹主动脉的破裂强度几乎相同。 h-Biotubes可以在4个月的包埋时间内在人体中形成​​，并且满足了用作血管移植物的机械要求。 （c）2015 Wiley Periodicals，Inc.J Biomed Mater Res Part B：Appl Biomater，104B：1431-1437，2016年。

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