...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >A novel photochemical cross-linking technology to improve luminal gain, vessel compliance, and buckling post-angioplasty in porcine arteries
【24h】

A novel photochemical cross-linking technology to improve luminal gain, vessel compliance, and buckling post-angioplasty in porcine arteries

机译：一种新颖的光化学交联技术，可提高猪动脉的管腔增益，血管顺应性和血管成形术后的屈曲

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Development of substituted 1,8-naphthalimides for photochemical cross-linking of biomolecules is the focus of this research. This study describes limited cross-linking of collagen in the artery wall to control recoil and buckling in arteries following balloon angioplasty. Isolated porcine arteries were overstretched (25%) with balloon angioplasty (BA) +/- light-activated naphthalimide treatment (NVS). Lumen size and recoil were measured as retention of stretch after angioplasty. Cross-sectional compliance and distensibility coefficients were measured as slope of cross-sectional area versus increasing hydrostatic pressure. Buckling was measured, with 30% axial pre-stretch and 200 mmHg, as deviation from the center line. Electron microscopy evaluation of collagen fibers was conducted. Results: Uninjured arteries have low compliance and low levels of buckling, whereas the BA-injured arteries demonstrated much greater compliance and buckling behavior. Treatment of the injured artery with NVS reduced buckling and demonstrated compliance midway between the two groups while retaining the increased luminal diameter imparted by angioplasty compared to untreated vessels. In summary, limited collagen cross-linking with NVS treatment resulted in lumen retention, as well as improved compliance without the accompanying rigidity and stiffness of conventional stent therapy or current cross-linking materials. This treatment shows great promise for dilation, repair and strengthening of arteries damaged by injury or vascular disease. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 375-384, 2016.
机译：本研究的重点是开发用于生物分子的光化学交联的取代1,8-萘二甲酰亚胺。这项研究描述了在球囊血管成形术后，动脉壁中胶原蛋白的有限交联以控制动脉的后座力和屈曲。使用球囊血管成形术（BA）+/-光激活的萘二甲酰亚胺处理（NVS）将孤立的猪动脉过度拉伸（25％）。测量管腔成形术后的管腔大小和后坐力作为拉伸的保持力。横截面顺应性和膨胀系数被测量为横截面面积对增加的静水压力的斜率。用30％的轴向预拉伸和200mmHg的屈曲来测量屈曲，以偏离中心线。进行胶原纤维的电子显微镜评价。结果：未受伤的动脉具有较低的顺应性和较低的屈曲水平，而BA受伤的动脉具有更大的顺应性和屈曲行为。与未治疗的血管相比，用NVS治疗受伤的动脉减少了屈曲，并显示了两组之间的顺应性，同时保留了由血管成形术赋予的增大的内腔直径。总之，通过NVS治疗进行有限的胶原蛋白交联会导致管腔滞留，并改善顺应性，而不会出现常规支架疗法或当前交联材料所具有的刚性和刚度。这种治疗方法有望扩大，修复和增强因损伤或血管疾病而受损的动脉。 （c）2015 Wiley Periodicals，Inc.J Biomed Mater Res Part B：Appl Biomater，104B：375-384，2016年。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号