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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Surface immobilization and bioactivity of TGF-1 inhibitor peptides for bone implant applications
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Surface immobilization and bioactivity of TGF-1 inhibitor peptides for bone implant applications

机译：TGF-1抑制剂肽在骨植入应用中的表面固定和生物活性

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摘要

TGF-1 is the most related cytokine with the production of fibrotic tissue. It plays an important role on the production of collagen by fibroblasts and other types of cells. The inhibition of this cytokine reduces fibrosis in various types of tissue. Biofunctionalization of dental and orthopedic implants with biomolecules enables modification of the physical, chemical and biochemical properties of their surfaces to improve its biological and clinical performance. Our objective was to develop a reliable method to immobilize oligopeptides on Ti surfaces to obtain a surface with TGF-1 inhibitory activity that will potentially minimize fibrotic encapsulation of implants during the process of osseointegration. We covalently immobilized TGF-1 inhibitor P17-peptides on Ti surfaces and assessed by characterizing each step of the process that we successfully biofunctionalized the implant surfaces. High amounts of peptides were anchored and homogeneously distributed on the surfaces with mechanical and thermochemical stability after in vitro simulated challenges. Notably, the immobilized peptides retained their TGF-1 inhibitory activity in vitro. Thus, these biofunctional coatings are potential candidates for inducing a fast and reliable osseointegration in vivo. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 385-394, 2016.
机译：TGF-1是与纤维化组织产生最相关的细胞因子。它在成纤维细胞和其他类型的细胞生产胶原蛋白中起重要作用。这种细胞因子的抑制作用减少了各种类型组织中的纤维化。用生物分子对牙科和整形外科植入物进行生物功能化可以改变其表面的物理，化学和生化特性，从而改善其生物学和临床性能。我们的目标是开发一种可靠的方法，将寡肽固定在Ti表面上，以获得具有TGF-1抑制活性的表面，该表面可能在骨整合过程中最大程度地减少植入物的纤维化封装。我们将TGF-1抑制剂P17肽共价固定在Ti表面上，并通过表征该过程的每个步骤进行评估，从而成功地对植入物表面进行了生物功能化。在体外模拟挑战后，大量的肽被锚定并均匀地分布在具有机械和热化学稳定性的表面上。值得注意的是，固定的肽在体外保留了其TGF-1抑制活性。因此，这些生物功能涂层是在体内诱导快速和可靠的骨整合的潜在候选者。 （c）2015 Wiley Periodicals，Inc.J Biomed Mater Res Part B：Appl Biomater，104B：385-394，2016年。

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