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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Cytocompatibility evaluation of NiMnSn meta-magnetic shape memory alloys for biomedical applications
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Cytocompatibility evaluation of NiMnSn meta-magnetic shape memory alloys for biomedical applications

机译：NiMnSn亚磁性形状记忆合金在生物医学中的细胞相容性评估

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Recently, magnetic shape memory alloys (MSMAs) have emerged as an interesting extension to conventional shape memory alloys (SMAs) due to their capacity to undergo reversible deformation in response to an externally applied magnetic field. Meta-magnetic SMAs (M-MSMAs) are a class of MSMAs that are able to transform magnetic energy to mechanical work by harnessing a magnetic-field induced phase transformation, and thus have the capacity to impose up to 10 times greater stress than conventional MSMAs. As such, M-MSMAs may hold substantial promise in biomedical applications requiring extracorporeal device activation. In the present study, the cytotoxicity and ion release from an Ni50Mn36Sn14 atomic percent composition M-MSMA were evaluated using NIH/3T3 fibroblasts. Initial studies showed that the viability of cells exposed to NiMnSn ion leachants was 60 to 67% of tissue culture polystyrene (TCP) controls over 10 to 14 days of culture. This represents a significant improvement in cytocompatibility relative to NiMnGa alloys, one of the most extensively studied MSMA systems, which have been reported to induce 80% cell death in only 48 h. Furthermore, NiMnSn M-MSMA associated cell viability was increased to 80% of TCP controls following layer-by-layer alloy coating with poly(allylamine hydrochloride)/poly(acrylic acid) [PAH/PAA]. Ion release measures revealed that the PAH/PAA coatings decreased total Sn and Mn ion release by 50% and 25%, respectively, and optical microscopy evaluation indicated that the coatings reduced NiMnSn surface oxidation. To our knowledge, this study presents the first cytotoxicity evaluation of NiMnSn M-MSMAs and lays the groundwork for their further biological evaluation. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 853-863, 2016.
机译：近来，磁性形状记忆合金（MSMA）作为常规形状记忆合金（SMA）的有趣扩展而出现，因为它们具有响应于外部施加的磁场而经历可逆变形的能力。亚磁SMA（M-MSMA）是一类MSMA，能够通过利用磁场感应的相变将磁能转换为机械功，因此具有比传统MSMA施加多达10倍大的应力的能力。因此，M-MSMA在需要体外设备激活的生物医学应用中可能具有广阔的前景。在本研究中，使用NIH / 3T3成纤维细胞评估了Ni50Mn36Sn14原子百分比组成M-MSMA的细胞毒性和离子释放。初步研究表明，在培养10至14天的过程中，暴露于NiMnSn离子浸出剂的细胞的活力为组织培养聚苯乙烯（TCP）对照的60％至67％。相对于NiMnGa合金而言，这是细胞相容性的显着改善，NiMnGa合金是研究最广泛的MSMA系统之一，据报道该系统仅在48小时内即可诱导80％的细胞死亡。此外，在用聚烯丙胺盐酸盐/聚丙烯酸[PAH / PAA]进行逐层合金涂层后，NiMnSn M-MSMA相关的细胞活力提高到TCP对照的80％。离子释放措施表明，PAH / PAA涂层分别使总Sn和Mn离子释放降低了50％和25％，光学显微镜评估表明，该涂层减少了NiMnSn的表面氧化。据我们所知，这项研究提出了对NiMnSn M-MSMAs的首次细胞毒性评估，并为进一步的生物学评估奠定了基础。 （c）2015 Wiley Periodicals，Inc.J Biomed Mater Res B部分：Appl Biomater，104B：853-863，2016。

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