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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Effect of PEO coating on bubble behavior within a polycarbonate microchannel array: A model for hemodialysis
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Effect of PEO coating on bubble behavior within a polycarbonate microchannel array: A model for hemodialysis

机译：PEO涂层对聚碳酸酯微通道阵列内气泡行为的影响：血液透析模型

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摘要

Obstruction of fluid flow by stationary bubbles in a microchannel hemodialyzer decreases filtration performance and increases damage to blood cells through flow maldistribution. A polyethylene oxide (PEO)-polybutadiene (PB)-polyethylene oxide surface modification, previously shown to reduce protein fouling and water/air contact angle in polycarbonate microchannel hemodialyzers, can improve microchannel wettability and may reduce bubble stagnation by lessening the resistive forces that compete with fluid flow. In this study, the effect of the PEO-PB-PEO coating on bubble retention in a microchannel array was investigated. Polycarbonate microchannel surfaces were coated with PEO-PB-PEO triblock polymer via radiolytic grafting. Channel obstruction was measured for coated and uncoated microchannels after injecting a short stream of air bubbles into the device under average nominal water velocities of 0.9 to 7.2cm/s in the channels. The presence of the PEO coating reduced obstruction of microchannels by stationary bubbles within the range of 1.8 to 3.6cm/s, average nominal velocity. Numerical simulations based on the lattice Boltzmann method indicate that beneficial effects may be due to the maintenance of a lubricating, thin liquid film around the bubble. The determined effective range of the PEO coating for bubble management serves as an important design constraint. These findings serve to validate the multiutility of the PEO-PB-PEO coating (bubble lubrication, biocompatibility, and therapeutic loading). (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 941-948, 2016.
机译：微通道血液透析器中固定气泡阻塞了流体流动，降低了过滤性能，并由于血流分布不均而增加了对血细胞的损害。先前显示，聚环氧乙烷（PEO）-聚丁二烯（PB）-聚环氧乙烷的表面改性可以减少聚碳酸酯微通道血液透析器中的蛋白质结垢和水/空气接触角，可以改善微通道的可湿性，并且可以通过降低与之竞争的阻力来减少气泡停滞流体流动。在这项研究中，研究了PEO-PB-PEO涂层对微通道阵列中气泡保留的影响。聚碳酸酯微通道表面通过辐射接枝涂覆有PEO-PB-PEO三嵌段聚合物。在通道中以0.9至7.2cm / s的平均标称水速向设备中注入一小段气泡后，测量涂层和未涂层​​微通道的通道阻塞情况。 PEO涂层的存在减少了平均标称速度在1.8至3.6cm / s范围内的固定气泡对微通道的阻塞。基于晶格玻尔兹曼方法的数值模拟表明，有益的效果可能是由于气泡周围保持润滑的薄液膜所致。确定的用于气泡管理的PEO涂层有效范围是重要的设计约束。这些发现有助于验证PEO-PB-PEO涂层的多功能性（气泡润滑，生物相容性和治疗负荷）。 （c）2015 Wiley Periodicals，Inc. J Biomed Mater Res B部分：Appl Biomater，104B：941-948，2016。

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